Vet Ophthalmol:一种新型疱疹病毒与慢性浅表角膜炎和增生性结膜炎相关

2018-04-26 cuiguizhong MedSci原创

美国加利福尼亚州加州大学戴维斯分校兽医学院的Gleeson MD近日在Vet Ophthalmol发表了一篇文章,他们在角膜溃疡的成年大角鸮中鉴定出一种新型的α疱疹病毒,并描述了其临床特征。

美国加利福尼亚州加州大学戴维斯分校兽医学院的Gleeson MD近日在Vet Ophthalmol发表了一篇文章,他们在角膜溃疡的成年大角鸮中鉴定出一种新型的α疱疹病毒,并描述了其临床特征。

一只成年大角鸮(Bubo virginianus; GHOW)表现出右眼复发性角膜溃疡病史(OD)。诊断结果包括溃疡性浅表角膜炎、增生性结膜炎和虹膜色素改变。药物治疗对溃疡起初不起作用,但在进行清创手术后迅速愈合。在用1%西多福韦、干扰素α2B滴眼液和口服L-赖氨酸进行局部抗病毒治疗后,增生性结膜炎得到明显改善。结膜活检组织病理学评估显示,具有上皮特征的可疑病毒性细胞病变和核内结构可疑病毒包涵体,这提示可能是病毒诱导的乳头状结膜炎。通过使用PCR和基因测序,鉴定出一种新型的α疱疹病毒,Strigid疱疹病毒1(StrHV1)。

这项病例首次报道了大角鸮中新型疱疹病毒的临床特征。同时,他们认为,疱疹病毒的鉴定对于结膜炎的治疗至关重要,角膜上皮清理促进了慢性角膜上皮缺陷的恢复。

原文出处:

Gleeson, M.D., et al., A novel herpesvirus associated with chronic superficial keratitis and proliferative conjunctivitis in a great horned owl (Bubo virginianus). Vet Ophthalmol, 2018.

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    2018-04-28 snowpeakxu
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  5. 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  6. 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createdName=tm10051990, createdTime=Wed Jul 25 00:37:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309590, encodeId=a11b309590ca, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Thu Apr 26 23:51:07 CST 2018, time=2018-04-26, status=1, ipAttribution=)]
    2018-04-27 哈哈869

    学了

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=309632, encodeId=ec3e3096322b, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Apr 27 05:14:30 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677494, encodeId=f35f16e749405, content=<a href='/topic/show?id=2ebbe881920' target=_blank style='color:#2F92EE;'>#结膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78819, encryptionId=2ebbe881920, topicName=结膜炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=803827523485, createdName=tm10051990, createdTime=Wed Jul 25 00:37:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309590, encodeId=a11b309590ca, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Thu Apr 26 23:51:07 CST 2018, time=2018-04-26, status=1, ipAttribution=)]
    2018-04-27 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

  8. 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createdBy=568152, createdName=snowpeakxu, createdTime=Sat Apr 28 14:37:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391796, encodeId=c67b1391e96d0, content=<a href='/topic/show?id=0e0590964e3' target=_blank style='color:#2F92EE;'>#角膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90964, encryptionId=0e0590964e3, topicName=角膜炎)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Apr 28 14:37:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541339, encodeId=96a315413392f, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, 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GetPortalCommentsPageByObjectIdResponse(id=309750, encodeId=ab48309e501e, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Fri Apr 27 09:16:40 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309739, encodeId=39a9309e39bd, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:25:54 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309632, encodeId=ec3e3096322b, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Apr 27 05:14:30 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677494, encodeId=f35f16e749405, content=<a href='/topic/show?id=2ebbe881920' target=_blank style='color:#2F92EE;'>#结膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78819, encryptionId=2ebbe881920, topicName=结膜炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=803827523485, createdName=tm10051990, createdTime=Wed Jul 25 00:37:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309590, encodeId=a11b309590ca, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Thu Apr 26 23:51:07 CST 2018, time=2018-04-26, status=1, ipAttribution=)]
    2018-04-27 changjiu

    学习一下谢谢

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1757308, encodeId=3ebc1e57308a7, content=<a href='/topic/show?id=2f354231613' target=_blank style='color:#2F92EE;'>#增生性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42316, encryptionId=2f354231613, topicName=增生性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f7c37300907, createdName=ms7514935887898259, createdTime=Wed May 23 06:37:00 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349133, encodeId=71a31349133b2, content=<a href='/topic/show?id=4337909284a' target=_blank style='color:#2F92EE;'>#角膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90928, encryptionId=4337909284a, topicName=角膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Sat Apr 28 14:37:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391796, encodeId=c67b1391e96d0, content=<a href='/topic/show?id=0e0590964e3' target=_blank style='color:#2F92EE;'>#角膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90964, encryptionId=0e0590964e3, topicName=角膜炎)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Apr 28 14:37:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541339, encodeId=96a315413392f, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Sat Apr 28 14:37:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580409, encodeId=54e415804097a, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sat Apr 28 14:37:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309750, encodeId=ab48309e501e, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Fri Apr 27 09:16:40 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309739, encodeId=39a9309e39bd, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:25:54 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309632, encodeId=ec3e3096322b, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Apr 27 05:14:30 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677494, encodeId=f35f16e749405, content=<a href='/topic/show?id=2ebbe881920' target=_blank style='color:#2F92EE;'>#结膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78819, encryptionId=2ebbe881920, topicName=结膜炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=803827523485, createdName=tm10051990, createdTime=Wed Jul 25 00:37:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309590, encodeId=a11b309590ca, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Thu Apr 26 23:51:07 CST 2018, time=2018-04-26, status=1, ipAttribution=)]
  10. [GetPortalCommentsPageByObjectIdResponse(id=1757308, encodeId=3ebc1e57308a7, content=<a href='/topic/show?id=2f354231613' target=_blank style='color:#2F92EE;'>#增生性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42316, encryptionId=2f354231613, topicName=增生性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f7c37300907, createdName=ms7514935887898259, createdTime=Wed May 23 06:37:00 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349133, encodeId=71a31349133b2, content=<a href='/topic/show?id=4337909284a' target=_blank style='color:#2F92EE;'>#角膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90928, encryptionId=4337909284a, topicName=角膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Sat Apr 28 14:37:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391796, encodeId=c67b1391e96d0, content=<a href='/topic/show?id=0e0590964e3' target=_blank style='color:#2F92EE;'>#角膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90964, encryptionId=0e0590964e3, topicName=角膜炎)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Apr 28 14:37:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541339, encodeId=96a315413392f, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Sat Apr 28 14:37:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580409, encodeId=54e415804097a, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sat Apr 28 14:37:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309750, encodeId=ab48309e501e, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Fri Apr 27 09:16:40 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309739, encodeId=39a9309e39bd, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:25:54 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309632, encodeId=ec3e3096322b, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Apr 27 05:14:30 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677494, encodeId=f35f16e749405, content=<a href='/topic/show?id=2ebbe881920' target=_blank style='color:#2F92EE;'>#结膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78819, encryptionId=2ebbe881920, topicName=结膜炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=803827523485, createdName=tm10051990, createdTime=Wed Jul 25 00:37:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309590, encodeId=a11b309590ca, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Thu Apr 26 23:51:07 CST 2018, time=2018-04-26, status=1, ipAttribution=)]
    2018-04-26 天地飞扬

    了解一下.谢谢分享!

    0

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Science:针对疱疹病毒的广谱性的药物新的曙光

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女孩因一吻感染疱疹病毒致瘫痪,“致命一吻”究竟是怎么回事

日前,一则“英国13岁少女瘫痪,只因为出生时妈妈的一个吻”的新闻引发热议。据外媒报道,英国一位现年13岁的女孩Melody不会走路不会说话还瘫痪在床,更无法照顾自己,然而这一切不幸的遭遇都源于在她刚出生两周时母亲的亲吻而导致疱疹病毒感染且伴有癫痫,虽然当时治好了,但2008年的复发却让女孩瘫痪,失去了行动和说话能力。这位女孩的母亲懊恼不已,想通过自己的不幸遭遇告诫其他的父母:“不要随便亲吻新生婴儿