Circulation:心肌损伤及2型心肌梗死患者的长期结局

2017-12-07 国际循环编辑部 国际循环

临床实践中2型心肌梗死及心肌损伤非常常见,但其长期结局尚不确定。近期Circulation发表的一项最新研究,评估心肌损伤及2型心肌梗死患者的长期结局,并探讨其风险分层。

临床实践中2型心肌梗死及心肌损伤非常常见,但其长期结局尚不确定。近期Circulation发表的一项最新研究,评估心肌损伤及2型心肌梗死患者的长期结局,并探讨其风险分层。

研究者英国爱丁堡大学的Andrew R.Chapman等,从一家三级医院心脏中心连续入选心肌肌钙蛋白I浓度增高(≥0.05μg/L)的2122例患者,按照心肌梗死的通用定义对其进行诊断。研究主要终点是全因死亡,次要终点包括主要不良心血管事件(MACE,非致死性心肌梗死或心血管死亡)及非心血管死亡。此外,研究还采用Cox回归模型评估原因别HR以评估竞争风险。

结果发现,被诊断为1型心肌梗死、2型心肌梗死及心肌损伤者分别为1171例(55.2%)、429例(20.2%)和522例(24.6%)。随访5年发现,与1型心肌梗死患者相比,2型心肌梗死及心肌损伤患者的全因死亡率均更高(62.5%vs.72.4%vs.36.7%)。进一步分析发现,与1型心肌梗死患者相比,2型心肌梗死及心肌损伤患者的死亡增加主要归因于非心血管原因(HR=2.32,95%CI:1.92~2.81)。尽管如此,与1型心肌梗死患者相比,2型心肌梗死及心肌损伤患者的粗MACE发生率相似(30.6%vs.32.6%),但校正协变量后存在显著差异(HR=0.82,95%CI:0.69~0.96)。此外,研究发现,冠心病是2型心肌梗死及心肌损伤患者MACE的独立预测因素(HR=1.71,95%CI:1.31~2.24)。

上述结果提示,尽管与1型心肌梗死患者相比,2型心肌梗死及心肌损伤患者的非心血管死亡增加,但MACE发生率相似。对于2型心肌梗死及心肌损伤患者,发现潜在的冠心病有助于进行有针对性的治疗以改变其未来风险。

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    2017-12-30 jihuaijun1112

    学习学习学习

    0

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    2017-12-14 大爰

    学习了谢谢分享!!

    0

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    2017-12-10 大爰

    学习了谢谢分享!!

    0

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    2017-12-07 天涯183

    非常好的文章.学习了

    0

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