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Blood：SGN-CD19B，以PBD为基础的抗CD19抗体结合物，对恶性B细胞肿瘤的治疗潜能。

2017-09-14 qinqiyun MedSci原创

SGN-CD19B恶性B细胞肿瘤抗CD19抗体
关注

复发性/难治性B细胞恶性肿瘤（如非霍奇金淋巴瘤 B-NHL、急性淋巴细胞白血病 B-ALL）患者预后较差。即使现在临床已经应用新的靶向治疗，但很多患者仍不能获得完全或持久缓解，提示我们应进一步改善现有的治疗方案。

中心点：

SGN-CD19B在体外具有广谱抗恶性B细胞系活性，包括双敲和三敲的淋巴瘤细胞系。

SGN-CD19B在B-NHL和B-ALL的预临床模型中表现出独特性的抗肿瘤特性。

摘要：

复发性/难治性B细胞恶性肿瘤（如非霍奇金淋巴瘤 B-NHL、急性淋巴细胞白血病 B-ALL）患者预后较差。即使现在临床已经应用新的靶向治疗，但很多患者仍不能获得完全或持久缓解，提示我们应进一步改善现有的治疗方案。

现研究人员对SGN-CD19B——以吡咯苯二氮平(PBD)为基础的抗CD19抗体结合物（ADC）——用于治疗B细胞恶性肿瘤的效果进行探究。与其他类型的ADCs相比，SGN-CD19B可提高治疗效果。表达CD19的肿瘤细胞迅速吸收SGN-CD19B，并释放PBD药物诱导DNA损伤，导致细胞周期（G2-M）阻滞而死亡。

SGN-CD19B对广谱恶性B细胞系均具有抗性，其可诱导移植恶性B细胞的小鼠模型获得持久缓解。

SGN-CD19B单剂量300mcg/kg即可诱导持久缓解；且联合利妥昔单抗时，100mcg/kg即可发挥作用。上述剂量明显低于其他ADC有效负荷所需要的药物剂量。

在猕猴模型中，SGN-CD19B可有效消除外周血和淋巴组织中的CD20+ B淋巴细胞，表明SGN-CD19B在药效学上具有良好的耐受性。

总而言之，临床预实验表明SGN-CD19B是一种高效的ADC。作用机制独特、广谱效价以及与利妥昔单抗结合的潜能，均提示SGN-CD19B或许可开辟一种新的恶性B细胞肿瘤的治疗方案。I期临床试验正在进行，探究SGN-CD19B对于复发性/难治性B-NHL的治疗潜能。

原始出处：

Maureen C. Ryan，et al.Therapeutic potential of SGN-CD19B， a PBD-based anti-CD19 drug conjugate， for treatment of B-cell malignancies.Blood.September 13，2017.https：//doi.org/10.1182/blood-2017-04-779389

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    2017-09-18 大爰

    学习了谢谢分享!!

    0

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    2017-09-16 xiaoyeshuang

    #B细胞#

    0

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    2017-09-16 dingxiaobo

    #CD19#

    0

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    2017-09-15 执着追梦

    学习.谢谢分享

    0

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    2017-09-15 tanxingdoctor

    学习啦!谢谢分享!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=245279, encodeId=44132452e989, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Sep 18 09:38:06 CST 2017, time=2017-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273211, encodeId=d9fd12e3211a2, content=<a href='/topic/show?id=310d383ef5' target=_blank style='color:#2F92EE;'>#B细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3837, encryptionId=310d383ef5, topicName=B细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Sat Sep 16 13:43:00 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416429, encodeId=ba1a1416429b7, content=<a href='/topic/show?id=924442e98f' target=_blank style='color:#2F92EE;'>#CD19#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4279, encryptionId=924442e98f, topicName=CD19)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1583186918, createdName=dingxiaobo, createdTime=Sat Sep 16 13:43:00 CST 2017, time=2017-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244165, encodeId=76f624416507, content=学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Fri Sep 15 07:00:50 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244107, encodeId=57e824410e9b, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Fri Sep 15 00:28:24 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244103, encodeId=e6d0244103c1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Sep 15 00:13:20 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244099, encodeId=6bd7244099b7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Sep 15 00:11:41 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244089, encodeId=ecf2244089e5, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Thu Sep 14 23:59:06 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244069, encodeId=709924406906, content=不错的文章值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Thu Sep 14 23:07:39 CST 2017, time=2017-09-14, status=1, ipAttribution=)]
    2017-09-15 yfjms

    学习了

    0

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    2017-09-15 yfjms

    学习了

    0

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    2017-09-14 luominglian113

    学习了.谢谢分享

    0

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    2017-09-14 131****2916

    不错的文章值得学习

    0