Eur Respir J:高海拔地区高COPD患病率:家庭空气污染是否起作用?

2019-02-11 xing.T MedSci原创

由此可见,COPD患病率和HAP在高海拔地区最高,并且是独立相关的。在这些资源匮乏的高海拔地区,似乎需要采取预防性干预措施。由于这项研究是中亚地区首个以肺量计测定为基础的流行病学研究之一,因此需要对其普遍性进行评估。

比较高海拔慢性阻塞性肺病(COPD)患病率的研究报道了相互矛盾的结果。然而,家庭空气污染(HAP)是COPD一个主要的危险因素,在以前的研究中大多没有考虑到,并且从未客观地测量过。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员的目的是比较低资源高海拔地区和低海拔地区之间COPD患病率及其危险因素,尤其是客观测量的HAP。

研究人员在吉尔吉斯斯坦农村地区的高海拔地区(海拔约2050米)和低海拔地区(海拔约750米)进行了一项基于人口的观察性研究。在随机选择的家庭中进行肺活量测定,以及测量了空气动力学直径<2.5μm(PM2.5)的室内颗粒物质,并对其他COPD危险因素进行问卷调查。描述性统计和多变量Logistic回归用于分析。

研究人员纳入了392名参与者:199名高海拔地区参与者和193名低海拔地区参与者。COPD在高海拔地区参与者中更为普遍(36.7% vs. 10.4%; p<0.001)。他们的平均PM2.5暴露也更高(290.0 vs. 72.0μg·m-3; p<0.001)。除较高PM2.5暴露(OR为3.174,95%CI为1.061-9.493)、海拔(OR为3.406,95%CI为1.483-7.825)、吸烟年数(OR为1.037,95%CI为1.005-1.070) )和年龄(OR为1.058,95%CI为1.037-1.079)也是导致高海拔地区人群COPD患病率较高的因素。

由此可见,COPD患病率和HAP在高海拔地区最高,并且是独立相关的。在这些资源匮乏的高海拔地区,似乎需要采取预防性干预措施。由于这项研究是中亚地区首个以肺量计测定为基础的流行病学研究之一,因此需要对其普遍性进行评估。

原始出处:

Evelyn A. Brakema,et al.High COPD prevalence at high altitude: does household air pollution play a role?.Eur Respir J.2018. https://erj.ersjournals.com/content/53/2/1801193

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    2019-09-27 zsyan
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    2019-02-12 龙胆草

    学习谢谢分享

    0

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