BMC Gastroenterology: 肿瘤位置作为胰腺导管腺癌切除后的存活指标

2019-05-13 不详 MedSci原创

最新的第8版AJCC分期系统强调了肿瘤大小的重要性,然而,肿瘤位置与肿瘤大小相结合的临床意义仍然未知。因此,本项研究旨在探究肿瘤位置与胰腺导管腺癌切除术的关系。

背景
最新的第8版AJCC分期系统强调了肿瘤大小的重要性,然而,肿瘤位置与肿瘤大小相结合的临床意义仍然未知。因此,本项研究旨在探究肿瘤位置与胰腺导管腺癌切除术的关系。

方法
研究人员对肿瘤位置在T1可切除的胰腺导管腺癌(PDAC)中的预后作用。选择来自数据库(2004-2014)的可切除PDAC患者进行倾向评分匹配分析。我们使用匹配的队列分析临床病理特征与患者生存之间的关系。

结果
在倾向评分匹配分析中包括889名患者,并选择4571名患者进行匹配研究。在T1患者中,与患有身体/尾部肿瘤的患者相比,胰头肿瘤患者的预后更差。多变量分析结果显示,胰体/尾部位置是T1 PDAC患者存活率更高的独立指标(风险比,0.69; 95%CI,0.52-0.93; P = 0.01)。修改后的分期系统比AJCC第8分期系统更有效。

结论
改良的分期系统表现出良好的生存率评估。肿瘤位置是T1可切除的PDAC患者的良好预后指标。

原始出处:

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    2020-01-28 许安
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