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Sci Rep：应用机械生物学算法研究经股动脉截肢患者异位骨的机械调节

2018-10-05 MedSci MedSci原创

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异位骨化（HO）是通常不是骨质的组织中骨形成的过程。大约60％的爆炸事故导致截肢的患者会发生HO这种情况。HO可以导致运动范围缩小、疼痛，神经刺激，并可以影响假肢使用，其原因是由机械、生物、局部和系统因素等引起。 与正常骨形成和重塑一样，预期异位骨响应机械刺激，并且理解这种关系可以提供对病理学的洞察。本研究旨在调查考虑机械和生物因素的生理2D计算模型是否可用于模拟经股动脉截肢的残肢中的HO。

异位骨化（HO）是通常不是骨质的组织中骨形成的过程。大约60％的爆炸事故导致截肢的患者会发生HO这种情况。HO可以导致运动范围缩小、疼痛，神经刺激，并可以影响假肢使用，其原因是由机械、生物、局部和系统因素等引起。

与正常骨形成和重塑一样，预期异位骨响应机械刺激，并且理解这种关系可以提供对病理学的洞察。本研究旨在调查考虑机械和生物因素的生理2D计算模型是否可用于模拟经股动脉截肢的残肢中的HO。研究发现，通过调整加载环境可以再现HO的特征形态。

通过改变股骨上的加载方向产生明显的效果；这可能与不同的初始手术干预有关，例如肌肉肌肉痉挛。此外，发现诸如通过敷料的负压的初始治疗改变了异位骨的形状。

原始出处：

Naomi M. Rosenberg, Anthony M. J. Bull, et al., Application of a mechanobiological algorithm to investigate mechanical mediation of heterotopic bone in trans-femoral amputees. Sci Rep. 2018; 8: 14196.

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    2018-12-05 d830382

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