Diabetes Care:减肥饮食对循环肠道微生物代谢物TMAO与骨密度的影响

2019-05-22 xing.T 网络

由此可见,TMAO可能在体重减轻期间防止BMD减少,但不依赖于常量营养素含量和基线糖尿病风险因素的饮食干预。膳食脂肪可以改变血浆左旋肉碱水平变化与BMD变化之间的关系。该研究结果强调了调查TMAO与糖尿病患者骨骼健康之间关系的重要性。

2型糖尿病与肥胖和骨骼健康改变有关,并且都受到肠道微生物群的影响。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员探究了减肥饮食诱导的肠道微生物群相关代谢物三甲胺N-氧化物(TMAO)及其前体(胆碱和左旋肉碱)的变化与考虑为糖尿病相关因素骨密度(BMD)的变化。

在为期2年的使用新型膳食策略预防超重试验(POUNDS Lost)中,264名通过DXA扫描测量BMD的超重和肥胖参与者被纳入分析。参与者被随机分配到四种不同的常量营养素摄入量中的一种。在汇集的参与者和不同的饮食组中进行关联分析。计算从基线到饮食干预后6个月的TMAO、胆碱和L-肉碱的血液水平的变化。

研究人员发现TMAO血浆水平从基线到6个月的更大程度降低与6个月和2年时全身BMD的更大损失相关(P=0.03和P=0.02)。TMAO的减少也与2年后脊柱BMD(P=0.005)更大损失有关,与体重变化无关。基线糖尿病状态和血糖水平未改变这种关联。左旋肉碱(一种TMAO的前体)的变化表明,对于6个月时脊柱BMD和髋部骨密度的变化,其与膳食脂肪摄入量相互作用(所有P<0.05)。左旋肉碱降低最少的参与者在低脂饮食组中的骨丢失比高脂肪饮食组少(脊柱P=0.03和髋部P=0.02)。 

由此可见,TMAO可能在体重减轻期间防止BMD减少,但不依赖于常量营养素含量和基线糖尿病风险因素的饮食干预。膳食脂肪可以改变血浆左旋肉碱水平变化与BMD变化之间的关系。该研究结果强调了调查TMAO与糖尿病患者骨骼健康之间关系的重要性。 

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    2021-11-20 湘雅科教

    已阅,受益匪浅。

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GetPortalCommentsPageByObjectIdResponse(id=1048267, encodeId=0534104826e29, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed May 22 18:27:00 CST 2019, time=2019-05-22, status=1, ipAttribution=)]
  5. 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GetPortalCommentsPageByObjectIdResponse(id=1048267, encodeId=0534104826e29, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed May 22 18:27:00 CST 2019, time=2019-05-22, status=1, ipAttribution=)]
  6. 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GetPortalCommentsPageByObjectIdResponse(id=1048267, encodeId=0534104826e29, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed May 22 18:27:00 CST 2019, time=2019-05-22, status=1, ipAttribution=)]
  7. 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GetPortalCommentsPageByObjectIdResponse(id=1048267, encodeId=0534104826e29, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed May 22 18:27:00 CST 2019, time=2019-05-22, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1072128, encodeId=23d110e21280a, content=已阅,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Sat Nov 20 10:35:55 CST 2021, time=2021-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798409, encodeId=66ba1e984094e, content=<a href='/topic/show?id=08276918eab' target=_blank style='color:#2F92EE;'>#生物代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69187, encryptionId=08276918eab, topicName=生物代谢)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, createdName=guguangxiang, createdTime=Wed Jun 19 07:27:00 CST 2019, time=2019-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659977, encodeId=0eb516599e7d1, content=<a href='/topic/show?id=24e82545262' target=_blank style='color:#2F92EE;'>#代谢物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25452, encryptionId=24e82545262, topicName=代谢物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c1225086772, createdName=旅苦化文_216, createdTime=Mon Aug 12 17:27:00 CST 2019, time=2019-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761137, encodeId=89a91e61137e6, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Apr 05 11:27:00 CST 2020, time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639132, encodeId=bc0d163913291, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Jun 12 23:27:00 CST 2019, time=2019-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825048, encodeId=f7f8182504848, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Aug 29 03:27:00 CST 2019, time=2019-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902256, encodeId=c07b19022563c, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Tue Jun 11 19:27:00 CST 2019, time=2019-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460358, encodeId=76a7146035807, content=<a href='/topic/show?id=96571e54928' target=_blank style='color:#2F92EE;'>#TMAO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17549, encryptionId=96571e54928, topicName=TMAO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0e56300497, createdName=JR19860221, createdTime=Fri May 24 06:27:00 CST 2019, time=2019-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366677, encodeId=7cdf3666e7c2, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Fri May 24 05:52:48 CST 2019, time=2019-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048267, encodeId=0534104826e29, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed May 22 18:27:00 CST 2019, time=2019-05-22, status=1, ipAttribution=)]
    2019-05-24 JR19860221
  9. [GetPortalCommentsPageByObjectIdResponse(id=1072128, encodeId=23d110e21280a, content=已阅,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Sat Nov 20 10:35:55 CST 2021, time=2021-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798409, encodeId=66ba1e984094e, content=<a href='/topic/show?id=08276918eab' target=_blank style='color:#2F92EE;'>#生物代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69187, encryptionId=08276918eab, topicName=生物代谢)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/iaP1mV9qBwx5tE2F4xcG1r4x1PibWvluIFLB8VsViakqNMBia2Z0wFibVrYwDEILvHB1OomzzTAAGy5MVl5BrdEv9Bw/132, createdBy=e11f100, 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content=<a href='/topic/show?id=96571e54928' target=_blank style='color:#2F92EE;'>#TMAO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17549, encryptionId=96571e54928, topicName=TMAO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0e56300497, createdName=JR19860221, createdTime=Fri May 24 06:27:00 CST 2019, time=2019-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366677, encodeId=7cdf3666e7c2, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Fri May 24 05:52:48 CST 2019, time=2019-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048267, encodeId=0534104826e29, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed May 22 18:27:00 CST 2019, time=2019-05-22, status=1, ipAttribution=)]
    2019-05-24 yjs木玉

    好好好好好好

    0

  10. 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encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sun Apr 05 11:27:00 CST 2020, time=2020-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639132, encodeId=bc0d163913291, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Jun 12 23:27:00 CST 2019, time=2019-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825048, encodeId=f7f8182504848, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, 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content=<a href='/topic/show?id=96571e54928' target=_blank style='color:#2F92EE;'>#TMAO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17549, encryptionId=96571e54928, topicName=TMAO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b0e56300497, createdName=JR19860221, createdTime=Fri May 24 06:27:00 CST 2019, time=2019-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366677, encodeId=7cdf3666e7c2, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Fri May 24 05:52:48 CST 2019, time=2019-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048267, encodeId=0534104826e29, content=什么时候有懒人用的减肥神药?, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Wed May 22 18:27:00 CST 2019, time=2019-05-22, status=1, ipAttribution=)]
    2019-05-22 CHANGE

    什么时候有懒人用的减肥神药?

    0