Lancet:基于新西兰初级医疗保健人群队列的心血管疾病风险预测模型

2018-05-08 zhangfan MedSci原创

研究人员对新西兰人群心血管疾病风险进行预测,该模型显示大部分人群心血管风险较低,新模型特别关注了不同种族及地域人群的心血管疾病风险差异

大多数心血管疾病风险预测模型建立于上个世纪,其队列参与者年龄较高,疾病风险较大,并且关于社会、经济和种族等因素的考察不全面。近日研究人员对新西兰初级保健人群的心血管疾病风险进行模型预测,并比较其与美国人口疾病预测模型的差异。

PREDICT考察新西兰初级保健人群以评估参与者心血管疾病风险状况。参与者基线无心血管、肾病以及充血性心力衰竭,依据临床、地域以及种族特征,采用COX回归模型考察参与者心血管疾病风险并与2013美国心脏病学会/美国心脏协会队列模型(PCES)进行比较。

401752名年龄30-74岁志愿者参与研究,平均随访4.2年,其中2/3的参与者随访时间超过5年,其中15386名患者(4%)发生心血管事件,其中致命性事件1507起,动脉粥样硬化性心血管疾病8549起。男女人群5年的总心血管事件发生率为3.2%和2.3%。多因素模型发现,最贫困1/5人群的心血管风险增加10%;毛利族、太平洋裔以及印第安裔人群的心血管疾病风险较欧洲、华裔以及其他亚裔人群高13-48%;亚裔人群较欧洲人群的心血管风险低25-33%。由于参与者年龄偏大,PCE模型对男女人群动脉粥样硬化性心血管疾病风险预测估计偏高,其中男性风险预测偏高40%,女性偏高60%,新预测模型所有性能指标优于PCEs。

研究人员对新西兰人群心血管疾病风险进行预测,该模型显示大部分人群心血管风险较低,新模型特别关注了不同种族及地域人群的心血管疾病风险差异。

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    2018-10-04 howi
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  5. 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    2018-05-08 xxx2501

    腻害腻害

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在ISAR-CABG临床试验中,接受药物洗脱支架(DES)治疗的大隐静脉移植物损伤患者的1年预后优于裸金属支架。本研究的目的旨在评估两个治疗组之间术后5年的预后差异。本研究将大隐静脉移植物损伤患者随机1:1分成DES组和裸金属支架组,主要终点事件是死亡、心梗或靶损伤血管再生(TLR)的组合事件。最终共纳入了610名患者,其中303名接受了DES治疗,307名接受了裸金属支架治疗。5年后,主要终点事

JACC:先心病患儿的大脑白质损伤可引起神经发育落后

在严重的先天性心脏病新生儿中,有60%患者被报道存在大脑损伤(BI),表现为大脑白质损伤或卒中。这些患者中也被报道过存在神经系统发育(ND)损伤,本研究的目的旨在评估单心室循环(SVP)和D-大动脉转位(d-TGA)新生儿的围手术期大脑损伤与神经系统发育情况的关系。本研究共纳入SVP和d-TGA的足月产婴儿,对其术前和术后进行大脑磁共振检查,并在12个月和30个月大时对患者的ND进行评估。最终,共

JACC:心肌应变性在心衰病人预后价值方面优于射血分数

目前,心衰的分级是根据患者的左室射血分数(LVEF)而定的,但其预后价值仍存在争议。心肌顺应性是独立于LVEF的一个心衰预后因素。本研究的目的旨在评估整体纵向应变(GLS)对心衰病人的预后价值。本研究纳入了4172名心衰病人,根据LVEF将其分成了LVEF减少组(LVEF <40%)、LVEF中等组(LVEF 40%-49%)和保留型LVEF组(LVEF ≥50%);同时,根据患者的GLS,

JACC:海藻糖通过激活自噬保护心梗后的心脏

海藻糖(TRE)是一种由低等生物合成的非还原性二糖,其可以通过激活自噬来保护处于各种应激状态下的细胞。本研究的目的旨在评估TRE对慢性缺血性重塑模型小鼠的影响。本研究对野生型(WT)小鼠和beclin 1+/-转基因小鼠进行永久性左前降支(LAD)冠脉结扎,之后对其进行安慰剂或者TRE处理,4周后,通过超声心动图、组织学检测、重量检测、血液动力学检测和生化检测对小鼠进行评估。分析结果显示,与接受安

盘点:JACC5月第2期研究一览

1. 心肌应变性在心衰病人预后价值方面优于射血分数DOI: 10.1016/j.jacc.2018.02.064目前,心衰的分级是根据患者的左室射血分数(LVEF)而定的,但其预后价值仍存在争议。心肌顺应性是独立于LVEF的一个心衰预后因素。本研究的目的旨在评估整体纵向应变(GLS)对心衰病人的预后价值。本研究纳入了4172名心衰病人,根据LVEF将其分成了LVEF减少组(LVEF <4