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Exp Dermatol：京尼平交联法可抑制3D皮肤等效物的收缩

2018-07-02 MedSci MedSci原创

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三维皮肤等价物在建造和使用中的持续收缩性限制了其在临床和药物实践中的应用。到目前为止，还没有有效的方法来抑制这种收缩。因此，本研究探究了低细胞毒性交联剂，1-乙基-3-三甲基氨基丙基碳二亚胺盐酸盐（EDC）和京尼平，以减少收缩。0.2和0.4mM的京尼平和EDC均对胶原包埋的成纤维细胞无毒，并可上调交联胶原中成纤维细胞的细胞外基质表达。中等浓度的京尼平，特别是0.4mM交联的胶原蛋白大大减少了3D

三维皮肤等价物在建造和使用中的持续收缩性限制了其在临床和药物实践中的应用。到目前为止，还没有有效的方法来抑制这种收缩。因此，本研究探究了低细胞毒性交联剂，1-乙基-3-三甲基氨基丙基碳二亚胺盐酸盐（EDC）和京尼平，以减少收缩。

0.2和0.4mM的京尼平和EDC均对胶原包埋的成纤维细胞无毒，并可上调交联胶原中成纤维细胞的细胞外基质表达。中等浓度的京尼平，特别是0.4mM交联的胶原蛋白大大减少了3D皮肤的收缩，从87％降低至28％（n = 9，p <0.05），而在0.4mM EDC交联后胶原在21天的随访期内仍然呈现64％的严重收缩。收缩抑制可能与凝胶僵硬度的增加和胶原降解的减缓有关。此外，京尼平交联不会损害表皮层的形成，也可改善皮肤等同物的表皮-真皮交界。

综上所述，该研究结果表明，京尼平交联可能促进三维皮肤等效物在临床实践和药理学测试中的应用。

原始出处：

Meng Q, Shen C. Construction of low contracted 3D skin equivalents by genipin crosslinking. Exp Dermatol. 2018 Jun 29. doi: 10.1111/exd.13725.


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    2018-07-07 1e1c07bdm01(暂无匿称)

    好

    0

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    2018-07-06 1e1c07bdm01(暂无匿称)

    好

    0

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    2018-07-04 ms9833124466084992

    #3D#

    0

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    2018-07-03 三生有幸9135

    学习一下

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=329876, encodeId=531c3298e635, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sat Jul 07 06:24:53 CST 2018, time=2018-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329633, encodeId=383332963302, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=2, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Fri Jul 06 05:32:21 CST 2018, time=2018-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336058, encodeId=57ac1336058f1, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Wed Jul 04 14:29:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328879, encodeId=dd073288e90d, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Tue Jul 03 06:55:03 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328868, encodeId=4fc4328868f3, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Tue Jul 03 06:28:52 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328852, encodeId=c73032885289, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Tue Jul 03 05:28:30 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328839, encodeId=03cf32883914, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Jul 03 00:35:07 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328829, encodeId=f637328829e8, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Jul 03 00:18:55 CST 2018, time=2018-07-03, status=1, ipAttribution=)]
    2018-07-03 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

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    2018-07-03 phoebeyan520

    学习了.谢谢分享

    0

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    2018-07-03 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-07-03 飛歌

    厉害了我的哥

    0