Chest:左心房容积作为心肾综合征靶器官损害的标志!

2018-06-04 xing.T MedSci原创

由此可见,一个简单的伴随体积分析的所有四个心腔CT肺血管造影显示体积的差异与即使在正常范围内的肾功能相关。左心房的差异最为明显。这一发现可能是心肾综合征的第一线索,可以作为早期治疗干预的靶点。

既往研究仅在进行性肾脏疾病的患者中通过心脏超声测量心腔大小。近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员的目的是探讨在CT肺血管造影评估的所有心腔容积和所有范围内肾脏功能之间的关系。

研究人员使用一种新的自动四腔容积分析技术分析了744例连续就诊的患者(2014年1月1日和12月31日之间)CT肺血管造影,这些患者没有肺栓塞,并评估了心腔体积和体表面积指数与估计的肾小球滤过率之间的相关性。

调整年龄后,所有心腔的体积,除了左心室,均与估计的肾小球滤过率呈负相关。估计的肾小球滤过率每降低10个单位,左心房(LA)、右心房和右心室体积指数分别降低了3.1%、2.3%和1.5%,分别有P<0.001、P=0.003和P=0.007。LA体积指数(LAVI)与eGFR呈显著正相关(r=-0.43;P<0.001)。在分类比较中,与估计的肾小球滤过率>90mL/min/1.73m2的患者相比,即使是最小的肾功能不全(估计的肾小球滤过率60-90mL/min/1.73m2)的患者LAVI也有10.3%增大(95%CI为3.1-17.9;P=0.004)。

由此可见,一个简单的伴随体积分析的所有四个心腔CT肺血管造影显示体积的差异与即使在正常范围内的肾功能相关。左心房的差异最为明显。这一发现可能是心肾综合征的第一线索,可以作为早期治疗干预的靶点。

原始出处:


Zach Rozenbaum,et al. Left atrial volume as a biomarker of target organ damage in cardio-nephrology: a study in a wide range of renal function.chest.2018. https://doi.org/10.1016/j.chest.2018.05.017

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    2018-11-01 Smile2680
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    2018-12-26 habb
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  5. 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createdName=惠映实验室, createdTime=Mon Jun 04 19:39:12 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321465, encodeId=ce2c3214650c, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Jun 04 19:20:02 CST 2018, time=2018-06-04, status=1, ipAttribution=)]
    2018-09-16 ylz8411
  6. 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  7. 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  8. 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createdName=惠映实验室, createdTime=Mon Jun 04 19:39:12 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321465, encodeId=ce2c3214650c, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Jun 04 19:20:02 CST 2018, time=2018-06-04, status=1, ipAttribution=)]
    2018-06-06 sodoo
  9. 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createdName=惠映实验室, createdTime=Mon Jun 04 19:39:12 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321465, encodeId=ce2c3214650c, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Jun 04 19:20:02 CST 2018, time=2018-06-04, status=1, ipAttribution=)]
    2018-06-04 惠映实验室

    学习了.谢谢分享.

    0

  10. 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createdName=惠映实验室, createdTime=Mon Jun 04 19:39:12 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321465, encodeId=ce2c3214650c, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Jun 04 19:20:02 CST 2018, time=2018-06-04, status=1, ipAttribution=)]
    2018-06-04 131****1460

    学习了受益匪浅

    0