Oncotarget:中性粒细胞与淋巴细胞比值预测神经胶质瘤患者生存情况!

2017-08-13 Emma MedSci原创

神经胶质瘤,是发生于神经外胚层的肿瘤。大多缓慢发病,自出现症状至就诊时间一般为数周至数月,少数可达数年。恶性程度高的和后颅窝肿瘤病史较短,较良性的或位于静区的肿瘤病史较长。

神经胶质瘤,是发生于神经外胚层的肿瘤。大多缓慢发病,自出现症状至就诊时间一般为数周至数月,少数可达数年。恶性程度高的和后颅窝肿瘤病史较短,较良性的或位于静区的肿瘤病史较长。肿瘤若有出血或囊变,症状会突然加重,甚至有类似脑血管病的发病过程。神经胶质瘤的临床症状可分两方面,一是颅内压增高症状,如头痛、呕吐、视力减退、复视、精神症状等;另一是肿瘤压迫、浸润、破坏脑组织所产生的局灶症状,早期可表现为刺激症状如局限性癫痫,后期表现为神经功能缺失症状如瘫痪。

神经胶质瘤系浸润性生长物,它和正常脑组织没有明显界限,难以完全切除,对放疗化疗不甚敏感,非常容易复发,手术难以切除或根本不能手术。化学药物和一般抗肿瘤的中药,因血脑屏障等因素的影响,疗效也不理想,因此神经胶质瘤至今仍是全身肿瘤中预后最差的肿瘤之一。

研究人员收集了PubMed,EMBASE,Cochrane Library和NCBI中的相关文献,评估中性粒细胞与淋巴细胞比值(NLR)在神经胶质瘤患者中的预后作用。研究显示,升高的NLR与神经胶质瘤患者的总生存期较差有关。

其中,共纳入了6项研究和1021例病例。研究人员对危险比(HR)和95%可信区间(CI)进行汇总,并进行了亚组分析和敏感性分析。对于神经胶质瘤患者总生存期(OS,overall survival),NLR升高合并HR值为1.48(95%CI,1.25-1.76)。在六项研究中,有五项研究使用4作为NLR的临界值,这五项研究的OS合并HR值为1.67(95%CI,1.37-2.03)。研究无显著异质性(I2 = 42.4%,P = 0.222)。

原始出处:
Zhang J, et al. Prognostic role of neutrophil lymphocyte ratio in patients with glioma. Oncotarget. 2017 Jul 22. doi: 10.18632/oncotarget.19484.

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    2017-10-01 仁医06
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    2017-08-16 luominglian113

    学习了,谢谢分享

    0

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/bfb3481a150cd7d0bee6aca90efb57b1.jpg, createdBy=3baf1618795, createdName=zgs0224, createdTime=Sun Aug 13 19:40:14 CST 2017, time=2017-08-13, status=1, ipAttribution=)]
    2017-08-15 杨柳青青

    签到学习了!……

    0

  5. 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  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/bfb3481a150cd7d0bee6aca90efb57b1.jpg, createdBy=3baf1618795, createdName=zgs0224, createdTime=Sun Aug 13 19:40:14 CST 2017, time=2017-08-13, status=1, ipAttribution=)]
  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/bfb3481a150cd7d0bee6aca90efb57b1.jpg, createdBy=3baf1618795, createdName=zgs0224, createdTime=Sun Aug 13 19:40:14 CST 2017, time=2017-08-13, status=1, ipAttribution=)]
    2017-08-13 随梦飞扬

    神经胶质瘤系浸润性生长物,它和正常脑组织没有明显界限,难以完全切除,对放疗化疗不甚敏感,非常容易复发,手术难以切除或根本不能手术。

    0

  9. 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createdName=wetgdt, createdTime=Tue Aug 15 10:19:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1315083, encodeId=cc91131508339, content=<a href='/topic/show?id=0a08e451815' target=_blank style='color:#2F92EE;'>#神经胶质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74518, encryptionId=0a08e451815, topicName=神经胶质瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Tue Aug 15 10:19:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233240, encodeId=c8ed23324058, content=神经胶质瘤系浸润性生长物,它和正常脑组织没有明显界限,难以完全切除,对放疗化疗不甚敏感,非常容易复发,手术难以切除或根本不能手术。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sun Aug 13 20:33:52 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233236, encodeId=9ed3233236ee, content=不错的,学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun Aug 13 20:19:33 CST 2017, time=2017-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233230, encodeId=cb182332303e, content=优质资源, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/bfb3481a150cd7d0bee6aca90efb57b1.jpg, createdBy=3baf1618795, createdName=zgs0224, createdTime=Sun Aug 13 19:40:14 CST 2017, time=2017-08-13, status=1, ipAttribution=)]
    2017-08-13 中医痴

    不错的,学习了,谢谢分享!

    0

  10. 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createdName=wetgdt, createdTime=Tue Aug 15 10:19:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1315083, encodeId=cc91131508339, content=<a href='/topic/show?id=0a08e451815' target=_blank style='color:#2F92EE;'>#神经胶质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74518, encryptionId=0a08e451815, topicName=神经胶质瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Tue Aug 15 10:19:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233240, encodeId=c8ed23324058, content=神经胶质瘤系浸润性生长物,它和正常脑组织没有明显界限,难以完全切除,对放疗化疗不甚敏感,非常容易复发,手术难以切除或根本不能手术。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/bfb3481a150cd7d0bee6aca90efb57b1.jpg, createdBy=3baf1618795, createdName=zgs0224, createdTime=Sun Aug 13 19:40:14 CST 2017, time=2017-08-13, status=1, ipAttribution=)]
    2017-08-13 zgs0224

    优质资源

    0

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由哈佛医学院的研究人员领导的一项新研究证实,一些可改变细胞代谢的实验性药物也能够在因相同基因发生改变而罹患癌症的小鼠体内阻止肿瘤生长,延长小鼠的生存期。 发表在12月14日《癌细胞》(Cancer Cell)杂志上的这项研究,将焦点放在了与异柠檬酸脱氢酶1(IDH1)编码基因遗传密码改变有关联的脑肿瘤上。这样的改变或突变存在于三分之一的大脑神经胶质瘤,以及一些血癌、皮肤癌、软组织癌和软骨

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神经胶质瘤是一种异质性原发性脑肿瘤,目前没有可以长期存活的治疗方法。诊断为胶质母细胞瘤的患者平均生存期14个月。症状通常仅在诊断前三个月才发生;因此,重要的是在症状发作前确定临床前肿瘤的指标。

J Pathol:单胺氧化酶A(MAOA)在经典型霍奇金淋巴瘤中高表达。

单胺氧化酶A(MAOA)是一种线粒体酶,研究表明它能够促进胶质瘤和前列腺癌的进展,但其表达和功能相关性的研究尚未在淋巴瘤中被开展。

Sci Rep:血糖和神经胶质瘤之间意想不到的联系

神经胶质瘤是一种异质性原发性脑肿瘤,目前没有可以长期存活的治疗方法。诊断为胶质母细胞瘤的患者平均生存期14个月。症状通常仅在诊断前三个月才发生;因此,重要的是在症状发作前确定临床前肿瘤的指标。