Macromol Biosci：将肝素整合至可光固化明胶 -甲基丙烯酰水凝胶中可促进软骨形成

2017-12-06 MedSci MedSci原创

多组分明胶-甲基丙烯酰（GelMA）水凝胶通常用于软骨组织工程（TE），但是优化其化学修饰以保持水凝胶的生物功能性经常被忽视。本研究探究了两种不同修饰方法——甲基丙烯酸化和硫醇化，以共聚GelMA和肝素的生物效应。通过凝血活酶时间和硫酸乙酰肝素缺陷型髓样细胞系增殖实验来评估甲基丙烯酸化肝素（HepMA）和硫醇化肝素（HepSH）的天然生物活性，结果显示，硫醇化可较好的保存抗凝和生长因子信号传导能力

多组分明胶-甲基丙烯酰（GelMA）水凝胶通常用于软骨组织工程（TE），但是优化其化学修饰以保持水凝胶的生物功能性经常被忽视。本研究探究了两种不同修饰方法——甲基丙烯酸化和硫醇化，以共聚GelMA和肝素的生物效应。

通过凝血活酶时间和硫酸乙酰肝素缺陷型髓样细胞系增殖实验来评估甲基丙烯酸化肝素（HepMA）和硫醇化肝素（HepSH）的天然生物活性，结果显示，硫醇化可较好的保存抗凝和生长因子信号传导能力。此外，在负载软骨细胞的GelMA水凝胶中掺入HepMA或HepSH，在软骨形成条件下培养5周，可促进细胞活力和软骨细胞表型。然而，与GelMA相比，只有GelMA-HepSH水凝胶在体外可产生明显更高的分化和基质沉积。

综上所述，该研究结果表明，与甲基丙烯酸化相比，硫醇-烯化学提供了将生物活性剂结合到明胶水凝胶中的有利策略，同时突出显示了GelMA-HepSH水凝胶作为软骨TE应用的候选材料。

原始出处：

Brown GCJ, Lim KS, et al., Covalent Incorporation of Heparin Improves Chondrogenesis in Photocurable Gelatin-Methacryloyl Hydrogels. Macromol Biosci. 2017 Dec;17(12). doi: 10.1002/mabi.201700158. Epub 2017 Oct 25.

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2018-09-15 yb6560

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2018-03-09 jiafufeng@yaho

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2017-12-08 tastas

#水凝胶#

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2017-12-08 10518094zz

#ACR#

29 0
[GetPortalCommentsPageByObjectIdResponse(id=1996109, encodeId=6a371996109b2, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sat Sep 15 03:29:00 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917823, encodeId=a4c3191e82328, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Jun 24 21:29:00 CST 2018, time=2018-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857539, encodeId=7fe4185e5397c, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Fri Mar 09 00:29:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308005, encodeId=18ab130800559, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Fri Dec 08 12:29:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400373, encodeId=873914003e366, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Fri Dec 08 12:29:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460941, encodeId=538a146094188, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Fri Dec 08 12:29:00 CST 2017, time=2017-12-08, status=1, ipAttribution=)]
2017-12-08 lishizhe

#凝胶#

30 0

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Macromol Biosci：将肝素整合至可光固化明胶 -甲基丙烯酰水凝胶中可促进软骨形成

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