Inflamm bowel dis:溃疡性结肠炎患者早期结肠全切除风险的临床预测分析

2017-07-26 xuyihan MedSci原创

溃疡性结肠炎患者中有一部分人群在确诊后数年后会进行结肠切除术,而哪些临床因素可以用来预测UC急性发作期住院的早期结肠癌切除的可能性呢?最近一项加拿大的基于人群的对照研究揭示了其中的秘密。

溃疡性结肠炎患者中有一部分人群在确诊后数年后会进行结肠切除术,而哪些临床因素可以用来预测UC急性发作期住院的早期结肠癌切除的可能性呢?最近一项加拿大的基于人群的对照研究揭示了其中的秘密。

研究人员选取了1996-2009年间患有UC的患者进行长期跟踪随访,共有489名患者入组。临床终点设置为3年内进行结肠切除术。并采用Logistic回归模型评估了确诊UC3年内星结肠切除术的临床变量,并预测了95%的可信区间(CI)。

研究结果表明,在3年内,UC患者中有57.7%进行了结肠切除术,同时,结肠切除术的几率每年下降12%,早期结肠切除术更有可能出现在35至64岁患者之间,男性要比女性的几率要大2倍左右,患者全结肠炎的患者更有可能行结肠切除术,而在住院期间使用英夫利西单抗治疗会增加手术几率。

所以,我们可以看出,住院治疗UC患者早期结肠切除术的风险较高,中年男子,农村居民以及英夫利西单抗治疗无效的男性患者尤其如此。

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    2017-10-29 nymo
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    2017-07-27 lxg951
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    2017-11-17 yuandd
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    2017-07-28 xiaoyeshuang
  6. [GetPortalCommentsPageByObjectIdResponse(id=1694993, encodeId=1f8516949936e, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Sun Oct 29 17:18:00 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057603, encodeId=fd2b205e60361, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Thu Jul 27 15:18:00 CST 2017, time=2017-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012333, encodeId=39a120123338c, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue May 01 09:18:00 CST 2018, time=2018-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977425, encodeId=fc2019e7425a0, content=<a href='/topic/show?id=57613630b9' target=_blank style='color:#2F92EE;'>#Bow#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3630, encryptionId=57613630b9, topicName=Bow)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Fri Nov 17 15:18:00 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454818, encodeId=9c031454818c2, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Fri Jul 28 08:18:00 CST 2017, time=2017-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512675, encodeId=3e7f15126e568, content=<a href='/topic/show?id=070d36311d' target=_blank style='color:#2F92EE;'>#bowel#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3631, encryptionId=070d36311d, topicName=bowel)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5b610492692, createdName=ms2536978994064944, createdTime=Fri Jul 28 08:18:00 CST 2017, time=2017-07-28, status=1, ipAttribution=)]