BMJ:前列腺增生继发下尿路症状临床治疗方法比较研究

2018-06-27 zhangfan MedSci原创

研究认为,前列腺动脉栓塞与电切治疗前列腺增生继发下尿路症状的临床疗效差异不显著,但栓塞对患者前列腺功能改善的效果劣于电切治疗,不良事件更少

近日研究人员比较了前列腺动脉栓塞术(PAE)与经尿道前列腺电切术(TURP)治疗前列腺增生继发下尿路症状的临床疗效

103名40岁以上前列腺增生继发难治性下尿路症状患者参与研究,PAE组患者接受250-400μm微球局部麻醉下动脉栓塞,而TURP组在脊髓或全身麻醉下进行切除手术,其中PAE组48人以及TURP 组51人参与终点评估,主要终点为术后12周国际前列腺症状评分(IPSS)变化,次要终点为前列腺功能变化。

PAE组术后12周IPSS得分减少9.23分,TURP组减少10.77分,组间差异不显著,但12周时,PAE组最大尿流率 (5.19 v 15.34 mL/s)、残余尿量减少(86.36 vs 199.98mL)、前列腺体积缩小(12.17 vs 30.27mL)以及压力流去阻塞效应(56% vs 93%)等方面显著劣于TURP组,PAE组患者不良事件率较低(36 vs 70起)

研究认为,前列腺动脉栓塞与电切治疗前列腺增生继发下尿路症状的临床疗效差异不显著,但栓塞对患者前列腺功能改善的效果劣于电切治疗,不良事件更少。

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    2019-02-26 gaoxiaoe
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    2019-04-12 gous
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encryptionId=78ece8958b2, topicName=继发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d33645837, createdName=feifers, createdTime=Fri Apr 12 11:56:00 CST 2019, time=2019-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336110, encodeId=3dea33611067, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/18/9fba4e8a3782366829a5645367fdb658.jpg, createdBy=b5732293938, createdName=青山颖钰, createdTime=Fri Aug 03 23:26:52 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327827, encodeId=314232e827af, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/18/9fba4e8a3782366829a5645367fdb658.jpg, createdBy=b5732293938, createdName=青山颖钰, createdTime=Fri Jun 29 05:41:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399253, encodeId=03ce1399253a5, content=<a href='/topic/show?id=cac364650c0' target=_blank style='color:#2F92EE;'>#治疗方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64650, encryptionId=cac364650c0, topicName=治疗方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8cec2200006, createdName=showtest, createdTime=Fri Jun 29 03:56:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404525, encodeId=ae29140452511, content=<a href='/topic/show?id=ce86201482f' target=_blank style='color:#2F92EE;'>#下尿路症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20148, encryptionId=ce86201482f, topicName=下尿路症状)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=edaf2479486, createdName=yilong5287543, createdTime=Fri Jun 29 03:56:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525822, encodeId=806615258226e, content=<a href='/topic/show?id=c93e228e889' target=_blank style='color:#2F92EE;'>#临床治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22878, encryptionId=c93e228e889, topicName=临床治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a68911667380, createdName=xuyong527, createdTime=Fri Jun 29 03:56:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003785, encodeId=98342003e858c, content=<a href='/topic/show?id=d82d4e52095' target=_blank style='color:#2F92EE;'>#尿路症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47520, encryptionId=d82d4e52095, topicName=尿路症状)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, createdName=aliceclz, createdTime=Mon Sep 03 13:56:00 CST 2018, time=2018-09-03, status=1, ipAttribution=)]
    2019-04-12 feifers
  5. [GetPortalCommentsPageByObjectIdResponse(id=1746844, encodeId=aa221e468440f, content=<a href='/topic/show?id=05dc201464d' target=_blank style='color:#2F92EE;'>#下尿路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20146, encryptionId=05dc201464d, topicName=下尿路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=57c735864207, createdName=hongbochen, createdTime=Thu May 09 03:56:00 CST 2019, time=2019-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848547, encodeId=809f184854e52, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/18/9fba4e8a3782366829a5645367fdb658.jpg, createdBy=b5732293938, createdName=青山颖钰, createdTime=Fri Jun 29 05:41:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399253, encodeId=03ce1399253a5, content=<a href='/topic/show?id=cac364650c0' target=_blank style='color:#2F92EE;'>#治疗方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64650, encryptionId=cac364650c0, topicName=治疗方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8cec2200006, createdName=showtest, createdTime=Fri Jun 29 03:56:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404525, encodeId=ae29140452511, content=<a href='/topic/show?id=ce86201482f' target=_blank style='color:#2F92EE;'>#下尿路症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20148, encryptionId=ce86201482f, topicName=下尿路症状)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=edaf2479486, createdName=yilong5287543, createdTime=Fri Jun 29 03:56:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525822, encodeId=806615258226e, content=<a href='/topic/show?id=c93e228e889' target=_blank style='color:#2F92EE;'>#临床治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22878, encryptionId=c93e228e889, topicName=临床治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a68911667380, createdName=xuyong527, createdTime=Fri Jun 29 03:56:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003785, encodeId=98342003e858c, content=<a href='/topic/show?id=d82d4e52095' target=_blank style='color:#2F92EE;'>#尿路症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47520, encryptionId=d82d4e52095, topicName=尿路症状)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, createdName=aliceclz, createdTime=Mon Sep 03 13:56:00 CST 2018, time=2018-09-03, status=1, ipAttribution=)]
    2018-08-03 青山颖钰

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1746844, encodeId=aa221e468440f, content=<a href='/topic/show?id=05dc201464d' target=_blank style='color:#2F92EE;'>#下尿路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20146, encryptionId=05dc201464d, topicName=下尿路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=57c735864207, createdName=hongbochen, createdTime=Thu May 09 03:56:00 CST 2019, time=2019-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848547, encodeId=809f184854e52, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, 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encryptionId=78ece8958b2, topicName=继发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d33645837, createdName=feifers, createdTime=Fri Apr 12 11:56:00 CST 2019, time=2019-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336110, encodeId=3dea33611067, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/18/9fba4e8a3782366829a5645367fdb658.jpg, createdBy=b5732293938, createdName=青山颖钰, createdTime=Fri Aug 03 23:26:52 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327827, encodeId=314232e827af, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/18/9fba4e8a3782366829a5645367fdb658.jpg, createdBy=b5732293938, createdName=青山颖钰, createdTime=Fri Jun 29 05:41:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399253, encodeId=03ce1399253a5, content=<a href='/topic/show?id=cac364650c0' target=_blank style='color:#2F92EE;'>#治疗方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64650, encryptionId=cac364650c0, topicName=治疗方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8cec2200006, createdName=showtest, createdTime=Fri Jun 29 03:56:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404525, encodeId=ae29140452511, content=<a href='/topic/show?id=ce86201482f' target=_blank style='color:#2F92EE;'>#下尿路症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20148, encryptionId=ce86201482f, topicName=下尿路症状)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=edaf2479486, createdName=yilong5287543, createdTime=Fri Jun 29 03:56:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525822, encodeId=806615258226e, content=<a href='/topic/show?id=c93e228e889' target=_blank style='color:#2F92EE;'>#临床治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22878, encryptionId=c93e228e889, topicName=临床治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a68911667380, createdName=xuyong527, createdTime=Fri Jun 29 03:56:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003785, encodeId=98342003e858c, content=<a href='/topic/show?id=d82d4e52095' target=_blank style='color:#2F92EE;'>#尿路症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47520, encryptionId=d82d4e52095, topicName=尿路症状)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, createdName=aliceclz, createdTime=Mon Sep 03 13:56:00 CST 2018, time=2018-09-03, status=1, ipAttribution=)]
    2018-06-29 青山颖钰

    学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1746844, encodeId=aa221e468440f, content=<a href='/topic/show?id=05dc201464d' target=_blank style='color:#2F92EE;'>#下尿路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20146, encryptionId=05dc201464d, topicName=下尿路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=57c735864207, createdName=hongbochen, createdTime=Thu May 09 03:56:00 CST 2019, time=2019-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848547, encodeId=809f184854e52, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, 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encryptionId=78ece8958b2, topicName=继发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d33645837, createdName=feifers, createdTime=Fri Apr 12 11:56:00 CST 2019, time=2019-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336110, encodeId=3dea33611067, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/18/9fba4e8a3782366829a5645367fdb658.jpg, createdBy=b5732293938, createdName=青山颖钰, createdTime=Fri Aug 03 23:26:52 CST 2018, time=2018-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327827, encodeId=314232e827af, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/18/9fba4e8a3782366829a5645367fdb658.jpg, createdBy=b5732293938, createdName=青山颖钰, createdTime=Fri Jun 29 05:41:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399253, encodeId=03ce1399253a5, content=<a href='/topic/show?id=cac364650c0' target=_blank style='color:#2F92EE;'>#治疗方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64650, encryptionId=cac364650c0, topicName=治疗方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8cec2200006, createdName=showtest, createdTime=Fri Jun 29 03:56:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1404525, encodeId=ae29140452511, content=<a href='/topic/show?id=ce86201482f' target=_blank style='color:#2F92EE;'>#下尿路症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20148, encryptionId=ce86201482f, topicName=下尿路症状)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=edaf2479486, createdName=yilong5287543, createdTime=Fri Jun 29 03:56:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525822, encodeId=806615258226e, content=<a href='/topic/show?id=c93e228e889' target=_blank style='color:#2F92EE;'>#临床治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22878, encryptionId=c93e228e889, topicName=临床治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a68911667380, createdName=xuyong527, createdTime=Fri Jun 29 03:56:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003785, encodeId=98342003e858c, 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  8. 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