Eur J Oncol Nurs:化疗诱导的神经病变幸存者中听力损失和耳鸣研究

2018-02-05 AlexYang MedSci原创

最近,有研究人员评估了幸存者这件的人口统计学、临床和疼痛特性、感觉测量、平衡、直觉压力、症状负担以及生活质量(QOL)之间的差异。这些幸存者接受了具有神经毒性的化疗(CTX)和报道具有化疗诱导的神经病变(CIN, n=217)、CIN和听力损失(CIN/HL,n=69)、或者CIN、听力损失和耳鸣。研究人员假设随着神经毒性的增加,幸存者具有更严重的治疗副作用结果。研究发现,与那些只患有CIN的幸存

最近,有研究人员评估了幸存者这件的人口统计学、临床和疼痛特性、感觉测量、平衡、直觉压力、症状负担以及生活质量(QOL)之间的差异。这些幸存者接受了具有神经毒性的化疗(CTX)和报道具有化疗诱导的神经病变(CIN, n=217)、CIN和听力损失(CIN/HL,n=69)、或者CIN、听力损失和耳鸣。研究人员假设随着神经毒性的增加,幸存者具有更严重的治疗副作用结果。

研究发现,与那些只患有CIN的幸存者相比,患有所有3种神经毒性的幸存者不太可能是女性,也不太可能报道具有照顾孩子的责任。另外,患有3中神经毒性的幸存者具有更高的疼痛得分,保护性知觉的更严重的丢失以及更差的定时起床情况。这些病人报道他们具有更高的焦虑水平和更差的QOL。对一些结果来说(CIN更长的持续时间、自我报道的平衡问题),与那些只患有CIN的幸存者相比,CIN/HL和CIN/HL/TIN幸存者具有更糟糕的结果。

最后,研究人员指出,他们的发现表明了与只患有CIN的幸存者相比,CIN/HL/TIN患者在最严重的症状负担上的风险增加,同时也包括了与感官损失和平衡变化上的明显问题,以及QOL的明显降低。

原始出处:

Miaskowski C, Paul SM, Mastick J et al. Hearing loss and tinnitus in survivors with chemotherapy-induced neuropathy. Eur J Oncol Nurs. Feb 2018.

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    2018-08-22 minlingfeng
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    2018-02-07 ysjykql
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    2018-02-07 axin012
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