NEJM:非细菌性血栓性心内膜炎-病例报道

2019-06-20 xing.T 网络

与化疗一起,患者开始用低分子量肝素进行抗凝治疗。患者的侧腹疼痛,心内膜炎的外周性表现和心脏瓣膜血栓均已消退。然而,在诊断后7个月,他死于进行性胰腺癌的并发症。

患者为一名健康的48岁男性,因双侧腹疼痛急剧发作而到急诊就诊。在过去的6个月里,他的体重意外减轻了约5公斤。

体检时双手指甲上观察到许多碎片状出血(如图A所示)。没有听到心脏杂音,但腹部皮肤很嫩,脾脏在左肋缘下方可触及。抽取血液培养物,并开始针对疑似细菌性心内膜炎进行抗生素治疗。经食道超声心动图显示三尖瓣和二尖瓣上的移位回声灶。腹部的计算机断层扫描显示胰腺颈部肿块,伴有多个肝脏病变,脾脏和肾脏有多个低密度影,这与梗塞一致(如图B所示)。



检查肝脏病变的活检标本显示为胰腺腺癌。血培养和血清学检测结果均为阴性。诊断为与转移性胰腺癌相关的非细菌性血栓性心内膜炎。

与化疗一起,患者开始用低分子量肝素进行抗凝治疗。患者的侧腹疼痛,心内膜炎的外周性表现和心脏瓣膜血栓均已消退。然而,在诊断后7个月,他死于进行性胰腺癌的并发症。
 
原始出处:

John B. Fournier,et al.Nonbacterial Thrombotic Endocarditis.N Engl J Med 2019;https://www.nejm.org/doi/full/10.1056/NEJMicm1804137

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    2019-06-20 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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    2019-06-20 smartxiuxiu

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1708533, encodeId=5ce11e085330f, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Tue Aug 06 21:35:00 CST 2019, time=2019-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078176, encodeId=1fc620e8176a4, content=<a href='/topic/show?id=53cb89101eb' target=_blank style='color:#2F92EE;'>#血栓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89101, encryptionId=53cb89101eb, topicName=血栓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sat Oct 12 20:35:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350729, encodeId=a5e31350e297c, content=<a href='/topic/show?id=a32d508e8c3' target=_blank style='color:#2F92EE;'>#心内膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50878, encryptionId=a32d508e8c3, topicName=心内膜炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jun 21 22:35:00 CST 2019, time=2019-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034860, encodeId=ff6d1034860b0, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jun 20 10:35:00 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368053, encodeId=f22c368053b3, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Thu Jun 20 09:23:26 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368052, encodeId=81c2368052e3, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Jun 20 09:12:59 CST 2019, time=2019-06-20, status=1, ipAttribution=)]
    2019-06-20 龙胆草

    学习谢谢分享

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