Am Heart J:治疗心力衰竭,卡维地洛更胜一筹

2018-05-23 岱西 中国循环杂志

不同的β受体阻滞剂,带来的临床效果也是不一样的。

不同的β受体阻滞剂,带来的临床效果也是不一样的。

比如发表在JACC上的一项研究就显示,静脉给予胺碘酮基础上,联合口服普萘洛尔,比联合口服美托洛尔抑制ICD术后电风暴方面更优。

而近来一项发表在Am Heart J的研究,美托洛尔又被“打败了”。研究显示,卡维地洛在改善射血分数降低的心力衰竭(HFrEF)患者生存率方面要更胜一筹。

研究显示,对于HFrEF患者,美托洛尔在降低死亡风险方面不敌卡维地洛(校正HR=1.069,P<0.001);治疗6年,生存概率也输于卡维地洛(55.6% vs 49.2%,P<0.001)。

亚组分析表明,对于男性、超过或低于65岁、治疗时间超过3个月和非糖尿病患者,上述结果均保持一致。

该研究共纳入2007-2015年期间确诊为HFrEF的患者114745例。研究者对其中43941对接受美托洛尔或卡维地洛的患者进行了倾向得分匹配分析。

其中,卡维地洛可非选择性地阻断β-受体、选择性地阻断α1-受体、大剂量时有阻断钙通道的作用。美托洛尔是一种选择性β1受体阻滞剂。

原始出处:
Ajam T, Ajam S, Devaraj S, et al.Effect of carvedilol vs metoprolol succinate on mortality in heart failure with reduced ejection fraction.Am Heart J. 2018 May;199:1-6. doi: 10.1016/j.ahj.2018.01.005. Epub 2018 Jan 31.

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    2018-05-25 zhaojie88
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    2018-05-25 slcumt
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    2018-05-23 wzb521zf

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