Diabetes Care:1型糖尿病父母与后代注意缺陷多动障碍的风险!

2018-01-27 xing.T MedSci原创

在这项回顾性队列研究中,研究人员发现,父母的T1D病史会使后代患ADHD的风险提高29%。然而,在今后的研究中需要进一步探究潜在的机制。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究旨在探讨1型糖尿病(T1D)家族史是否与后代注意缺陷多动障碍(ADHD)的发病率增加相关。

研究人员从全国范围内的瑞典国立医院出院登记和瑞典门诊登记中心确定了T1D患者,并与瑞典多代登记中心进行链接确定其后代。研究人员采用Cox回归模型来计算相比于一般人群,T1D父母后代患ADHD的风险比(HR)。

该研究共有15615名受试者其父母被诊断为T1D。在对混杂因素进行控制后,T1D患者的后代发生ADHD的风险显著增加,其风险比为1.29(95%可信区间为1.15-1.42)。母亲为T1D患者的受试者(风险比为1.35[95%CI为1.18-1.55])相比于父亲是T1D的受试者(风险比为1.20[95%可信区间为1.03-1.41])发生ADHD的风险增加,但差异无统计学意义。

在这项回顾性队列研究中,研究人员发现,父母的T1D病史会使后代患ADHD的风险提高29%。然而,在今后的研究中需要进一步探究潜在的机制。

原始出处:


Jianguang Ji,et al. Type 1 Diabetes in Parents and Risk of Attention Deficit Hyperactivity Disorder in Offspring: A Population-Based Study in Sweden.Diabetes Care 2018. https://doi.org/10.2337/dc17-0592

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channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Jan 27 09:00:27 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282460, encodeId=ecdb28246048, content=还是一个好样的事情, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Jan 27 09:00:03 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282459, encodeId=490a282459c9, content=这样的人是比较新鲜, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Jan 27 08:59:54 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
    2018-01-27 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1901950, encodeId=21ae1901950bb, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Tue Jan 01 06:16:00 CST 2019, time=2019-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968839, encodeId=0b0719688397a, content=<a href='/topic/show?id=01be430e1c3' target=_blank style='color:#2F92EE;'>#多动障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43071, encryptionId=01be430e1c3, topicName=多动障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, 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topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Apr 07 01:16:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638371, encodeId=707f16383e143, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Mar 31 10:16:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369985, encodeId=31c2136998500, content=<a href='/topic/show?id=b6e76501e50' target=_blank style='color:#2F92EE;'>#注意缺陷多动障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65017, encryptionId=b6e76501e50, topicName=注意缺陷多动障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b505306, createdName=医生2394, createdTime=Sun Jan 28 23:16:00 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282462, encodeId=80d42824622a, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jan 27 09:03:32 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282461, encodeId=92af28246128, content=后代多动障碍的高发, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Jan 27 09:00:27 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282460, encodeId=ecdb28246048, content=还是一个好样的事情, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Jan 27 09:00:03 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282459, encodeId=490a282459c9, content=这样的人是比较新鲜, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Jan 27 08:59:54 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
    2018-01-27 雾夜芭蕾

    后代多动障碍的高发

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1901950, encodeId=21ae1901950bb, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Tue Jan 01 06:16:00 CST 2019, time=2019-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968839, encodeId=0b0719688397a, content=<a href='/topic/show?id=01be430e1c3' target=_blank style='color:#2F92EE;'>#多动障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43071, encryptionId=01be430e1c3, topicName=多动障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, 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topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Apr 07 01:16:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638371, encodeId=707f16383e143, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Mar 31 10:16:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369985, encodeId=31c2136998500, content=<a href='/topic/show?id=b6e76501e50' target=_blank style='color:#2F92EE;'>#注意缺陷多动障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65017, encryptionId=b6e76501e50, topicName=注意缺陷多动障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b505306, createdName=医生2394, createdTime=Sun Jan 28 23:16:00 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282462, encodeId=80d42824622a, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jan 27 09:03:32 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282461, encodeId=92af28246128, content=后代多动障碍的高发, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Jan 27 09:00:27 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282460, encodeId=ecdb28246048, content=还是一个好样的事情, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Jan 27 09:00:03 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282459, encodeId=490a282459c9, content=这样的人是比较新鲜, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Jan 27 08:59:54 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
    2018-01-27 雾夜芭蕾

    还是一个好样的事情

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1901950, encodeId=21ae1901950bb, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Tue Jan 01 06:16:00 CST 2019, time=2019-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968839, encodeId=0b0719688397a, content=<a href='/topic/show?id=01be430e1c3' target=_blank style='color:#2F92EE;'>#多动障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43071, encryptionId=01be430e1c3, topicName=多动障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, 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channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Jan 27 09:00:27 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282460, encodeId=ecdb28246048, content=还是一个好样的事情, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Jan 27 09:00:03 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282459, encodeId=490a282459c9, content=这样的人是比较新鲜, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBkyaelI9ia3n9SbuKmBdaY0PqCOzd0nhRUstroXmUmXZ5EBTmibtLEvCCIpyHAqxQXGfZz49ibrwjkg/0, createdBy=39781652829, createdName=雾夜芭蕾, createdTime=Sat Jan 27 08:59:54 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
    2018-01-27 雾夜芭蕾

    这样的人是比较新鲜

    0

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对于伴有多支血管病变的1型糖尿病(T1D)患者,搭桥手术或者经皮冠脉介入治疗(PCI)的收益哪种更大尚未阐明。本研究纳入了瑞典1995年至2013年行首次多血管重建手术的T1D患者,并通过多个数据库对患者的临床信息和预后进行全面的评估分析。最终,共纳入了683名接受搭桥手术治疗的患者和1863名接受PCI治疗的患者,经过平均10.6年时间的随访,搭桥治疗组的53%患者和PCI治疗组的45%患者死亡

Diabetes:抑制12/15-LOX可预防T1D小鼠模型的β细胞氧化应激和血糖恶化。

胰岛β细胞功能障碍和侵略性巨噬细胞活跃是1型糖尿病(T1D)的早期病理特点。T1D的β细胞和巨噬细胞分泌12/15-脂肪氧合酶(12/15-LOX),12/15-LOX会转变成促炎性脂质和脂质过氧化物,反过来又β细胞功能异常和巨噬细胞活性进一步恶化。

Diabetes Obes Metab:1型糖尿病患者非严重低血糖与体重增加有关!

总之,该研究的分析显示T1D患者非严重低血糖和体重增加之间具有显著的关联。

Diabetes:降低1型糖尿病患者的血尿酸对肾功能和血管的影响!

FBX降低收缩压和调节肾脏对高血糖的RE反应,但不影响RAAS或NO,这表明PUA可能增加其他血流动力学或炎症机制,以控制出球小动脉高血糖的肾脏反应。正在进行的临床试验将确定1型糖尿病患者PUA降低的心肾结局。

Diabetes:单次高强度间歇训练可以减少1型糖尿病患者低血糖的发生!

目前的研究结果表明单次HIIT会迅速降低1型糖尿病患者和NAH患者随后低血糖的意识,但不影响IAH患者,减轻低血糖引起的认知功能障碍。运动诱导的乳酸在介导这些效应中的作用,可能是通过作为大脑的替代燃料,应进一步进行探讨。

Diabetes Care:在青少年T1D患者中,血浆尿酸水平不能用来评价心肾功能

在青少年1型糖尿病(T1D)患者中,血浆尿酸(PUA)和肾脏和心血管参数之间的关系还不是很清楚。研究人员的目的是探索性分析研究青少年1型糖尿病患者中PUA和估计肾小球滤过率(eGFR),尿白蛋白肌酐比值(ACR),血压,血管内皮功能和动脉僵硬度之间的关联。研究人员也在健康对照(HC)参与者中进行了研究对这些。在青少年1型糖尿病心肾干预试验(AdDIT)中,研究人员共招募188例T1D患者和65例H