Free Radic Res:适当的O3/O2治疗可增强大脑和耳蜗的酶催化和非酶促抗氧化

2017-10-22 AlexYang MedSci原创

线粒体损伤和氧化胁迫是常见的噪音诱导的听力损失(NIHL)发病机理。最近,有研究人员探究了 O2/O3混合物(氧气/臭氧)疗法对线粒体诱导的听力损伤和噪音诱导的氧化胁迫在小鼠大脑和耳蜗中的保护性作用。研究人员将小鼠分成了4个小组,1组为对照组、2组为噪音暴露小组(100dB)、3组为噪音加O2/O3、4组为O2/O3(30微克/毫升)处理组。在处理14天后,研究人员对小鼠进行局部麻醉,并移除小鼠的

线粒体损伤和氧化胁迫是常见的噪音诱导的听力损失(NIHL)发病机理。最近,有研究人员探究了 O2/O3混合物(氧气/臭氧)疗法对线粒体诱导的听力损伤和噪音诱导的氧化胁迫在小鼠大脑和耳蜗中的保护性作用。研究人员将小鼠分成了4个小组,1组为对照组、2组为噪音暴露小组(100dB)、3组为噪音加O2/O3、4组为O2/O3(30微克/毫升)处理组。在处理14天后,研究人员对小鼠进行局部麻醉,并移除小鼠的大脑和耳蜗组织,用来对在大脑和耳蜗组织中组织病理损伤、氧化胁迫和线粒体功能异常进行评估。研究发现,噪音能够引起小鼠大脑和耳蜗的病理损伤、氧化胁迫和线粒体功能异常。同样,O2/O3疗法的日常治疗(30微克/毫升静脉内注射)有效的增加了大脑和耳蜗中的酶催化和非酶促抗氧化作用,并且该作用能够抑制病理损伤、氧化胁迫、活性氧形成以及线粒体膜电位(MMP)破坏以及因噪音引起的细胞色素c的释放。最后,研究人员指出,这些发现表明了适度的O2/O3疗法可以增强大脑和耳蜗中的酶催化和非酶促抗氧化作用,从而避免NIHL的发生。原始出处:Nasezadeh P, Shahi F, Fridoni M et al. M

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    2018-02-26 jeanqiuqiu
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    2017-10-25 半夏微凉

    学习了谢谢分享

    0

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    2017-10-23 yjs木玉

    好好好好好好好好

    0

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    2017-10-23 飛歌

    学习了很有用不错

    0

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    2017-10-23 cherry bomb

    学习了谢谢分享

    0

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    2017-10-22 惠映实验室

    学习了.谢谢.

    0

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