JAHA:自发性冠状动脉夹层患者的特征及临床结局

2019-05-14 xing.T 网络

在患有急性心肌梗塞的患者中,SCAD患者的死亡风险较低,这主要归因于他们的年龄较小、女性以及动脉粥样硬化危险因素的低患病率。在最初就诊后数年,复发SCAD的风险持续存在。纤维肌性发育不良和偏头痛患者复发SCAD的风险较高。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究的目的是报告自发性冠状动脉夹层(SCAD)患者的特征和长期临床结局,并确定与复发性SCAD相关的因素。

这是一项回顾性队列研究,其中纳入了2006年至2016年期间接受冠状动脉造影评估急性心肌梗死的患者。在26598例主要诊断为急性心肌梗死的住院患者中,208例(0.78%)被诊断为SCAD。 SCAD患者较年轻(49.0±11.6 vs. 65.6±12.2岁),更可能是女性(88.9% vs. 31.6%)。动脉粥样硬化危险因素,如高血压、高脂血症、肥胖和糖尿病不太常见。

中位随访时间为4.7年。SCAD患者的死亡率较低(1年死亡率:2.4% vs. 8.8%; P<0.001)。在使用倾向评分匹配来控制年龄、性别和合并症的差异后,死亡率的差异不再存在,这表明SCAD患者的死亡率较低主要归因于他们的基线特征。22名患者(10.6%)出现复发性SCAD。多变量Cox回归模型显示伴随的纤维肌性发育不良(风险比为5.1; 95%CI为1.6-15.8;P=0.005)和偏头痛(风险比为3.4;95%CI为1.4-8.4; P=0.008)与SCAD复发的风险增加相关。

在患有急性心肌梗塞的患者中,SCAD患者的死亡风险较低,这主要归因于他们的年龄较小、女性以及动脉粥样硬化危险因素的低患病率。在最初就诊后数年,复发SCAD的风险持续存在。纤维肌性发育不良和偏头痛患者复发SCAD的风险较高。 

原始出处:

Ryan Clare.et al.Characteristics and Clinical Outcomes of Patients With Spontaneous Coronary Artery Dissection.JAHA.2019.https://www.ahajournals.org/doi/full/10.1161/JAHA.119.012570

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    2019-05-16 zhaohui6731
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    2019-05-16 sodoo

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