Radiology:心脏CT中心外膜脂肪分布在致心律失常性右室发育不良/心肌病诊断的价值

2019-03-19 shaosai MedSci原创

Radiology:心脏CT中心外膜脂肪分布在致心律失常性右室发育不良/心肌病诊断的价值

本研究旨在比较致心律失常性右室发育不良/心肌病(ARVD/C)患者与健康志愿者心外膜脂肪分布差异。

本研究共纳入了44例ARVD/C患者及45名健康志愿者,进行心脏CT检查。测量胸内脂肪组织体积、纵膈脂肪组织(MAT)和心外膜脂肪组织(EAT)。EAT进一步分为右心室(RV)EAT、左心室(LV)EAT和心房旁EAT和以上区域校正后MAT。利用Logistic回归和ROC曲线分析评价心外膜脂肪与ARVD/C的相关性。

结果为,ARVD/C患者总EAT体积要明显高于正常对照组(中位数分别为98 mL vs 76 mL; P = .04)。在局部,在ARVD/C患者LV、RV EAT体积要明显高于健康对照组,尤其是当与MAT校正后(中位数LV EAT指数分别为: 0.49 vs 0.15,; 中位数RV EAT指数分别为: 0.91 vs 0.52; P< .0005)。诊断ARVD/C的最佳截断值为LV EAT指数0.24,敏感性和特异性分别为91%、71%。在两组间心房旁EAT体积和总胸内脂肪组织体积并无统计学差异。RV直径与总EAT指数和LV EAT指数具有正性相关性(r = 0.21、P = .05和r = 0.33、P = .002)。

本研究表明,在致心律失常性右室发育不良/心肌病患者中右心室和左心室心外膜脂肪要较高,尤其是临近左心室处,这与病变的严重性具有相关性,这有助于与正常人相鉴别。

原始出处:

Aliyari Ghasabeh M, Te Riele ASJM, James CA,et al.Epicardial Fat Distribution Assessed with Cardiac CT in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy.Radiology.DOI:10.1148/radiol.2018180224

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    2021-03-16 苏小雨

    学习了很好

    0

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    2019-03-21 neurowu
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    2019-03-20 183****7028

    学习

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