GUT:阿托伐他汀和舒林酸居然可以预防结直肠腺瘤!

2017-11-12 MedSci MedSci原创

人群个体对一些预防性干预的反应是互不相同的。近期,一项发表在杂志GUT上的研究旨在确定化学预防剂的功效是否在非肿瘤动物与结直肠肿瘤动物中有所不同。研究者们将舒林酸(Sulindac)和/或阿托伐他汀(Atorvastatin)施用于治疗开始时具有已知肿瘤负荷状态的Apc+/Min-FCCC小鼠。此项研究中的雄性小鼠(6-8周龄)均接受结肠镜检查,并接受舒林酸(300ppm),阿托伐他汀(100pp

人群个体对一些预防性干预的反应是互不相同的。近期,一项发表在杂志GUT上的研究旨在确定化学预防剂的功效是否在非肿瘤动物与结直肠肿瘤动物中有所不同。研究者们将舒林酸(Sulindac)和/或阿托伐他汀(Atorvastatin)施用于治疗开始时具有已知肿瘤负荷状态的Apc+/Min-FCCC小鼠。此项研究中的雄性小鼠(6-8周龄)均接受结肠镜检查,并接受舒林酸(300ppm),阿托伐他汀(100ppm)或舒林酸/阿托伐他汀的食物或者正常对照食物。从处理14周(组织病理学)或7天(基因表达)的小鼠中收集组织。在用舒林酸、阿托伐他汀或两者处理的SW480结肠癌细胞上进行细胞周期分析。此项研究结果显示:基线时未处理的小鼠中,结肠直肠腺瘤的多样性比基线时无肿瘤的小鼠高3.6倍(P = 0.002)。阿托伐他汀完全抑制基线时无肿瘤的小鼠中形成微腺瘤(P = 0.018),并改变了与干/祖细胞相关基因的表达。与未经治疗的肿瘤小鼠相比,用舒林酸/阿托伐他汀治疗的肿瘤小鼠的结肠直肠腺瘤的多样性降低43%(P = 0.049)。舒林酸/阿托伐他汀显着增加Hoxb13和Rprm的表达,提示细胞周期调控在肿瘤

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    2018-03-24 cooco
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    2017-12-13 jyzxjiangqin

    阿托伐他汀的作用.

    0

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    2017-12-02 jyzxjiangqin

    阿托伐他汀的应用.

    0

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    2017-11-23 虈亣靌

    好好学习努力向上

    0

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    2017-11-21 jyzxjiangqin

    阿托伐他汀的用途.

    0

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    2017-11-17 虈亣靌

    好消息.值得学习

    0

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    2017-11-12 虈亣靌

    优质资源.共同学习

    0

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