Stroke:降低卒中风险不妨“减盐”

2018-05-28 吴星 环球医学

2018年5月,发表在《Stroke》的一项由中国和美国科学家进行的研究考察了中国人群食盐摄入量的纵向变化和卒中风险。

2018年5月,发表在《Stroke》的一项由中国和美国科学家进行的研究考察了中国人群食盐摄入量的纵向变化和卒中风险。

背景和目的:盐摄入与卒中之间相关性的数据不一致。这种易变性可能是由于多数研究在单一时间点评估了盐摄入,这可能无法准确描述整个观察期的盐摄入。

方法:纳入来自开滦研究的77605名参与者。研究者于2006、2008和2010年通过调查问卷评估了食盐摄入量。使用潜在混合模型确定2006~2010年的盐摄入轨迹。鉴别出2010~2015年的卒中病例,并通过病历记录审查予以证实。Cox比例风险模型用于考察调整了可能的混杂因素(包括年龄、性别、生活方式、社会经济状态、体重指数[BMI]、药物使用情况、血压和脂蛋白特征)后,盐摄入轨迹与卒中风险之间的相关性。

结果:鉴别出5个不同的盐摄入轨迹:中等-稳定(59241人)、中等-下降(9268人)、中等-增长(2975人)、低-增长(2879人)和高-下降(3242人)。5年的随访期发生了1564例卒中病例。与中等-稳定盐摄入轨迹相比,中等-下降盐摄入轨迹的人具有显著较低的脑梗死风险(调整风险比[HR],0.76;95% 置信区间[CI],0.63~0.92),但是颅内出血风险并非如此(调整HR,0.84;95% CI,0.55~1.29)。进一步调整2006或2010年食盐摄入量后,结果相似。当仅用基线食盐摄入量作为暴露时,较高的食盐摄入量与较高的卒中风险之间存在显著的剂量效应关系(P=0.006)。

结论:盐摄入的改变与卒中风险相关。这些数据支持减盐的饮食建议。

原始出处:

Yun Li, Zhe Huang, Cheng Jin, et.al. Longitudinal Change of Perceived Salt Intake and Stroke Risk in a Chinese Population. Stroke. 2018;49:1332-1339

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    2018-05-30 易水河

    低盐饮食有益健康

    0

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    2018-05-29 baihao215

    这个盐太难该了

    0

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    2018-05-29 baihao215

    这个盐盐盐

    0

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    2018-05-28 131****1460

    学习了受益匪浅

    0

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    2018-05-28 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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