Gastroenterology:肥胖与体重变化和女性憩室炎风险的关系

2018-07-04 MedSci MedSci原创

几乎没有证据表明肥胖与憩室炎有关,尤其是女性。对此研究人员对一大群女性进行了肥胖,体重变化和憩室炎发病率的综合评估以期能获得相关性的结论。

背景与目的
几乎没有证据表明肥胖与憩室炎有关,尤其是女性。对此研究人员对一大群女性进行了肥胖,体重变化和憩室炎发病率的综合评估以期能获得相关性的结论。

方法
研究人员对46079名健康女性进行了一项前瞻性队列研究,该研究年龄跨度为61-89岁,基线特征中并没有憩室炎,憩室出血,癌症或炎症性肠病。研究人员使用Cox比例风险模型来评估憩室炎的风险与体重指数(BMI),腰围,腰臀比和从18岁到现在的体重变化之间的关联。主要终点是首次发生憩室炎,需要抗生素治疗或住院治疗。

结果
在6年的随访中共记录了1084例憩室炎事件。调整其他危险因素后,与BMI≥35.0妇女相比具有BMI <22.5更易出现憩室炎,风险比为1.42 ,95%置信区间[CI],1.08-1.85。与最低五分位数的女性相比,最高五分位女性的发生憩室炎危险比为腰围1.35(95%CI,1.02-1.78),腰臀比为1.40(95%CI,1.07-1.84)。与从18岁到现在保持体重的女性相比,那些体重增加≥20kg的女性憩室炎风险增加73%(95%CI,27%-136%)。

结论
在为期6年的随访期间,研究人员观察到肥胖与女性憩室炎风险之间存在正相关关系。成年期体重增加也与风险增加有关。

原始出处:

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    2019-05-02 许安
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    2018-07-12 jyzxjiangqin

    肥胖与体重变化的关系.

    0

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    2018-07-11 大爰

    学习了谢谢分享!!

    0

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    2018-07-06 zutt