AJG: 大麻素在胃轻瘫和相关疾病患者中的应用

2019-06-19 不详 MedSci原创

由于缺乏效果明确的治疗方案,胃轻瘫(Gp)正变成一种具有挑战性的疾病。本研究旨在探究大麻素在治疗胃轻瘫患者中的疗效。

背景及目标: 
由于缺乏效果明确的治疗方案,轻瘫(Gp)正变成一种具有挑战性的疾病。本研究旨在探究大麻素在治疗轻瘫患者中的疗效。

方法:
研究人员收集了从2018年6月至2018年9月间在一家三级转诊中心进行随访时出现Gp症状的门诊病人的临床资料,并要求所有患者填写了有关其症状和当前治疗方法的问卷。

结果:
在197例患者中,近一半患者(n = 92,46.7%)使用大麻素(包括四氢大麻酚(n = 63),屈大麻酚(n = 36))。其中,大麻素对Gp症状的改善最为明显(四氢大麻酚为93.5%,大麻二酚为81.3%,屈大麻酚为47.2%)。大麻素最常用于吸烟(n = 46)。服用大麻素的患者较年轻(41.0±15.4 vs 48.0±15.9岁; P <0.01),并且与没有大麻素病史的患者相比,胃轻瘫症状主要症状指数总分(3.4±1.0 vs 2.8±1.3; P <0.01)也更加明显。

结论:
三分之一的Gp症状患者都积极使用大麻素治疗慢性Gp症状。大多数患者认为大麻素的症状有所改善。服用大麻素的患者比不服用大麻素的患者更年轻。

原始出处:
Jehangir, Asad. Et al. Cannabinoid Use in Patients With Gastroparesis and Related Disorders. American Journal of Gastroenterology. 2019.

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    2019-10-03 minzju5052
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    2019-06-21 kcb069
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