JCEM:研究表明多囊卵巢患者患糖尿病的风险大大提高

2017-08-30 佚名 Medicalxpress

根据内分泌协会临床内分泌与代谢杂志发表的一项新研究,患有多囊卵巢综合征(PCOS)的妇女具有发展2型糖尿病(T2D)的较高风险,并且在较早的年龄被诊断出病情。全国范围内的研究首次显示了T2D发展与PCOS之间的联系。

根据内分泌协会临床内分泌与代谢杂志发表的一项新研究,患有多囊卵巢综合征(PCOS)的妇女具有发展2型糖尿病(T2D)的较高风险,并且在较早的年龄被诊断出病情。全国范围内的研究首次显示了T2D发展与PCOS之间的联系。


丹麦欧登塞大学医院Dorte Glintborg博士说:“许多PCOS患者肥胖,但PCOS发生糖尿病的风险尚不得知。” “在这项研究中,我们发现与对照组相比,PCOS患者的糖尿病诊断会早四年。

根据激素健康网络,估计美国有500万到600万的女性患有PCOS。它是育龄妇女最常见的内分泌状况之一。

具有PCOS的妇女产生的睾丸激素和其他雄激素的产生量略高。虽然这些生殖激素通常与男性有关,但妇女也有少量。女性多囊卵巢综合症患者的雄激素水平升高可能导致月经不规则或缺乏,不孕不育,体重增加,痤疮或脸部及身体多余的毛发。具有PCOS的妇女也面临较高的发展其他健康问题的风险,如糖尿病。

为了确定PCOS妇女T2D发展的风险,研究人员研究了两类PCOS患者:所有绝经前在国家病人登记册(18,477名妇女)诊断为PCOS的丹麦妇女,另有1 122名在丹麦的欧登塞大学医院检查过确诊PCOS的妇女。测试了当地参与者的胰岛素和葡萄糖水平,胆固醇,甘油三酯和睾酮水平。将具有PCOS的妇女与没有发生疾病的年龄匹配的女性进行比较。从PCOS的每个女性的国家患者登记中随机选择三名没有PCOS的女性。

研究人员发现,与没有发生疾病的同行相比,PCOS患者发生T2D的可能性高出四倍。接受诊断为T2D的PCOS妇女的平均年龄为31岁。没有PCOS和诊断为T2D的妇女的平均年龄为35岁。

研究人员还研究了与PCOS中T2D发展相关的各种因素,如年龄,体重指数(BMI),怀孕数目和口服避孕药的处方。研究人员使用丹麦国家病人登记册中的诊断标准和国家处方注册处的医疗处方来作出调查结果。

身体质量指数,胰岛素和葡萄糖水平以及甘油三酯与T2D发展呈正相关,而T2D发生率则较高。

该研究的作者指出,BMI和空腹血糖水平是PCOS患者T2D发展的最佳预测因子。然而,年龄增加不应该作为风险因素纳入未来的指南,因为本研究中大多数糖尿病病例在40岁之前发现。作者补充说,需要进一步的研究来评估口服避孕药的作用和怀孕次数对PCOS患者T2D发展的风险的影响。

Glintborg说:“在PCOS中发展T2D的风险增加是一个重要的发现。 “糖尿病可能在年轻的时候发展,筛查糖尿病是很重要的,特别是在肥胖和有PCOS的妇女中。
原始出处:
Dorte Glintborg,Katrine Hass Rubin,Mads Nybo.et al.Development and risk factors of type 2 diabetes in a nationwide population of women with polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism

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    2017-10-10 柳叶一刀
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    2018-03-22 achengzhao
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    2017-08-30 qinxyang

    谢谢分享

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1777656, encodeId=5bfe1e776563b, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Tue Oct 10 12:00:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063038, encodeId=bf39206303890, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Thu Mar 22 07:00:00 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718389, encodeId=fca91e18389d5, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Sat Aug 04 14:00:00 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238721, encodeId=f4ae238e212e, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/31/208d170d6afc2977ff569bbd0fe70ce1.jpg, createdBy=6e811377745, createdName=qinxyang, createdTime=Wed Aug 30 16:19:49 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238718, encodeId=2652238e18b7, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/31/208d170d6afc2977ff569bbd0fe70ce1.jpg, createdBy=6e811377745, createdName=qinxyang, createdTime=Wed Aug 30 16:19:14 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238680, encodeId=e85123868029, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Aug 30 13:10:39 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238673, encodeId=780f2386e30d, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Aug 30 12:28:34 CST 2017, time=2017-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238662, encodeId=d346238662f2, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Aug 30 11:58:17 CST 2017, time=2017-08-30, status=1, ipAttribution=)]
    2017-08-30 qinxyang

    谢谢分享

    0

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    2017-08-30 清风拂面

    谢谢分享.学习了

    0

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    2017-08-30 天地飞扬

    谢谢分享!

    0

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    2017-08-30 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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