Am J Med:提高心肺适能可降低冠心病和死亡风险

2016-10-17 MedSci MedSci原创

本项研究的目的是评估心肺适能和与冠心病事件和全因死亡风险之间的关联;我们假设对于没有冠心病家族史的个体,心肺适能与这些风险之间存在负相关。 研究纳入了57,999例患者,年龄53±13岁,49%为女性,29%为黑人,均来自FIT项目。心肺适能以基于运动应激试验时的代谢当量表示。通过患者自我报道收集一级亲属冠心病病史等信息。校正人口和心血管病危险因素后,使用Cox比例风险模型评估心肺适能与冠心

本项研究的目的是评估心肺适能和与冠心病事件和全因死亡风险之间的关联;我们假设对于没有冠心病家族史的个体,心肺适能与这些风险之间存在负相关。

研究纳入了57,999例患者,年龄53±13岁,49%为女性,29%为黑人,均来自FIT项目。心肺适能以基于运动应激试验时的代谢当量表示。通过患者自我报道收集一级亲属冠心病病史等信息。校正人口和心血管病危险因素后,使用Cox比例风险模型评估心肺适能与冠心病事件和死亡风险之间的关联,分别随访5.5(5.6)和10.4(6.8)年。

总体而言,51%的患者存在冠心病家族史。心肺适能每增加1个单位的代谢当量,冠心病事件和死亡风险就会下降,且与有没有冠心病家族史无关,具体数值为:有冠心病家族史:冠心病事件风险 HR 0.87 (0.84, 0.89),死亡风险 HR 0.83 (0.82, 0.84);无冠心病家族史:冠心病事件风险 HR 0.87 (0.85,0.89),死亡风险 HR 0.83 (0.82, 0.85)。冠心病家族史和不同心肺适能、性别或年龄之间不存在显著的交互作用(所有P值>0.05)。

结果表明,不管你有没有冠心病家族史,提高心肺适能均可以降低冠心病事件和死亡风险,所以我们应该规律运动,尤其是有冠心病家族史的亲们。

原始出处:

Mahmoud Al Rifai,et al.Higher Fitness is Strongly Protective in Patients with Family History of Heart Disease: The FIT Project.Am J Med.Articles in Press

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    2017-09-05 aids222
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    2016-10-24 1e0ece0dm09(暂无匿称)

    谢谢指点学习

    0

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