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PLoS One.：肿瘤T1弛豫时间可评估贝伐单抗抗肿瘤血管生成疗法的反应

2015-06-27 范伟 译 MedSci原创

肿瘤T1弛豫时间贝伐单抗抗肿瘤血管生成疗法
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目的：评估是否肿瘤T1弛豫时间可用于评估贝伐单抗抗肿瘤血管生成疗法的反应。方法：12只患有皮下SKOV3ip1-LC卵巢肿瘤雌性裸体小鼠施以贝伐单抗(6.25 ug / g，n = 6)或PBS(对照，n = 6)治疗每周两次进行两周。起始治疗后，肿瘤T1地图在之前，两天，2周内产生。肿瘤重量采用磁共振MR和尸体剖检进行检查。进

目的：评估是否肿瘤T1弛豫时间可用于评估贝伐单抗抗肿瘤血管生成疗法的反应。

方法：12只患有皮下SKOV3ip1-LC卵巢肿瘤雌性裸体小鼠施以贝伐单抗(6.25 ug / g，n = 6)或PBS(对照，n = 6)治疗每周两次进行两周。起始治疗后，肿瘤T1地图在之前，两天，2周内产生。肿瘤重量采用磁共振MR和尸体剖检进行检查。进行肿瘤微血管密度、增殖和细胞凋亡的组织学研究。

结果：贝伐单抗治疗致使肿瘤生长抑制(p < 0.04，n = 6)，确认了治疗的效果。在起始治疗后贝伐单抗治疗小鼠2天，2周后(p <.05，n = 6)肿瘤T1弛豫时间增加了。贝伐单抗治疗组，微血管密度降低了59%，细胞增殖(Ki67 +)降低了50%(p <.001，n = 6)，但没有凋亡。

结论：研究结果表明，肿瘤T1弛豫时间的增加与贝伐单抗治疗卵巢癌模型小鼠的反应有关联，这可能作为早期的信号反应。

原始出处：

Ravoori MK1, Nishimura M2, Singh SP1, Lu C3, Han L1, Hobbs BP4, Pradeep S3, Choi HJ3, Bankson JA5, Sood AK6, Kundra V7.Tumor T1 Relaxation Time for Assessing Response to Bevacizumab AntiAngiogenic Therapy in a Mouse Ovarian Cancer Model.PLoS One. 2015 Jun 22;10(6):e0131095. doi: 10.1371/journal.pone.0131095.

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    2016-05-25 huangshifeng

    #抗肿瘤血管生成#

    0

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    2015-11-24 meichuangyi

    #肿瘤血管#

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    2015-10-13 119337457

    #Plos one#

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    2015-09-16 肉我只吃一口

    #肿瘤血管生成#

    0

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    2015-06-29 sunrural_42825359

    #贝伐#

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