Diabetes Care:A1C和血糖对非心脏和心脏手术患者术后死亡率的影响!

2018-02-14 xing.T MedSci原创

由此可见,尽管A1C与围手术期血糖呈正相关,但控制血糖后,其与30天死亡率无关。围手术期血糖可预测30天死亡率,非心脏手术呈线性,心脏手术患者呈线性。这证实了围手术期血糖控制与手术疗效相关,但A1C反映前期血糖变化,是一个不太有用的预测指标。

糖化血红蛋白(A1C)用于评估择期手术患者,因为高血糖增加了不良事件的发生风险。然而,A1C、葡萄糖与手术治疗的效果之间的相互作用尚不清楚,这三个因素常常只是同时考虑两个。近日,糖尿病领域权威杂志Diabetes Care上发表了研究文章,研究人员评估了术前A1C与围手术期血糖控制之间的关系,及其与30天死亡率之间的相关性。

研究人员通过对杜克大学健康系统内431480例手术进行回顾性分析以确定术前A1C水平与围手术期血糖(在术后前3天的平均值)与30天死亡率之间的相关性,其中对6684例非心脏和6393例心脏手术患者进行A1C和血糖测量。研究人员使用广义相加模型来明确非线性关系。

研究人员发现A1C与葡萄糖密切相关。血糖与死亡率呈正相关,对于非心脏手术病例:平均血糖100mg/dL死亡率为1%,平均血糖200mg/dL死亡率为1.6%。对于心脏手术,血糖和死亡率之间存在显著的U型关系,从100mg/dL的4.5%到140mg/dL的最低值1.5%,再上升到200mg/dL的6.9%。当控制非心脏或心脏手术血糖时,A1C与30天死亡率不相关。

由此可见,尽管A1C与围手术期血糖呈正相关,但控制血糖后,其与30天死亡率无关。围手术期血糖可预测30天死亡率,非心脏手术呈线性,心脏手术患者呈线性。这证实了围手术期血糖控制与手术疗效相关,但A1C反映前期血糖变化,是一个不太有用的预测指标。

原始出处:

Willem van den Boom,et al. Effect of A1C and Glucose on Postoperative Mortality in Noncardiac and Cardiac Surgeries.Diabetes Care 2018. https://doi.org/10.2337/dc17-2232

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    2018-02-26 惠映实验室

    学习.谢谢分享.

    0

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    2018-02-14 1ddf0692m34(暂无匿称)

    学习了涨知识

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    2018-02-14 131****1460

    学习了受益匪浅

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