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Braz Oral Res：全身应用褪黑激素可增加下颌骨牵引成骨中的骨形成

2018-10-07 MedSci MedSci原创

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本研究旨在探讨不同剂量的全身褪黑素对大鼠下颌骨牵张成骨（DO）过程中新骨形成的影响。 对30只成年雌性Sprague-Dawley大鼠进行下颌DO，随机分为3组：对照组（CNT），褪黑素剂量1（MLT-D1）和褪黑素剂量2（MLT-D2）。手术后进行了为期五天的潜伏等待期和十天的牵引期。术后，来自MLT-D1和MLT-D2组的大鼠分别在第7天，第14天，第21天，第28天和第35天接受25和

本研究旨在探讨不同剂量的全身褪黑素对大鼠下颌骨牵张成骨（DO）过程中新骨形成的影响。

对30只成年雌性Sprague-Dawley大鼠进行下颌DO，随机分为3组：对照组（CNT），褪黑素剂量1（MLT-D1）和褪黑素剂量2（MLT-D2）。手术后进行了为期五天的潜伏等待期和十天的牵引期。术后，来自MLT-D1和MLT-D2组的大鼠分别在第7天，第14天，第21天，第28天和第35天接受25和50mg/kg褪黑激素。在牵引后28天，即在手术后43天对动物实施安乐死。

组织学和组织形态学分析显示，在所有三组中，牵开骨区域充满新骨形成。MLT-D2组显示出最新的骨形成，其次是MLT-D1和CNT。褪黑激素组比CNT具有更多的破骨细胞（p <0.05）。褪黑素组中成骨细胞的数量高于CNT组，MLT-D2的破骨细胞数多于MLT-D1组（p <0.05）。最后，褪黑素组中骨桥蛋白（OPN）和血管内皮生长因子（VEGF）的水平高于CNT组，MLT-D2具有比MLT-D1更高的OPN和VEGF水平（p <0.05）。

综上所述，该研究表明全身应用褪黑激素可以增加DO中的新骨形成。

原始出处：

Acikan I, Mehmet G, et al., Systemic melatonin application increases bone formation in mandibular distr action osteogenesis. Braz Oral Res. 2018 Sep 21;32:e85. doi: 10.1590/1807-3107bor-2018.vol32.0085.

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    2019-03-30 xlysu

    #下颌#

    0

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    2018-12-24 apple57298871

    学习了

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    2018-12-22 apple57298871

    学习了

    0

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    2018-12-20 apple57298871

    学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1699745, encodeId=86091699e450c, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Sat Mar 30 09:23:00 CST 2019, time=2019-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356250, encodeId=1dd33562504e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Mon Dec 24 07:14:13 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356070, encodeId=10103560e0ec, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Sat Dec 22 07:20:21 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355903, encodeId=dc8a35590383, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Thu Dec 20 08:53:19 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355816, encodeId=a4f935581603, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Wed Dec 19 10:04:23 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355378, encodeId=9a423553e811, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Fri Dec 14 08:18:53 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355275, encodeId=8c0b3552e56a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Thu Dec 13 07:09:25 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355178, encodeId=dfaa3551e84c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Wed Dec 12 06:55:32 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355068, encodeId=49ae355068ed, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Tue Dec 11 07:11:24 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354976, encodeId=9a613549e68f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Mon Dec 10 07:17:00 CST 2018, time=2018-12-10, status=1, ipAttribution=)]
    2018-12-19 apple57298871

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1699745, encodeId=86091699e450c, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Sat Mar 30 09:23:00 CST 2019, time=2019-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356250, encodeId=1dd33562504e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Mon Dec 24 07:14:13 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356070, encodeId=10103560e0ec, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Sat Dec 22 07:20:21 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355903, encodeId=dc8a35590383, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Thu Dec 20 08:53:19 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355816, encodeId=a4f935581603, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Wed Dec 19 10:04:23 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355378, encodeId=9a423553e811, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Fri Dec 14 08:18:53 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355275, encodeId=8c0b3552e56a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Thu Dec 13 07:09:25 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355178, encodeId=dfaa3551e84c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Wed Dec 12 06:55:32 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355068, encodeId=49ae355068ed, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Tue Dec 11 07:11:24 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354976, encodeId=9a613549e68f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Mon Dec 10 07:17:00 CST 2018, time=2018-12-10, status=1, ipAttribution=)]
    2018-12-14 apple57298871

    学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1699745, encodeId=86091699e450c, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Sat Mar 30 09:23:00 CST 2019, time=2019-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356250, encodeId=1dd33562504e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Mon Dec 24 07:14:13 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356070, encodeId=10103560e0ec, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Sat Dec 22 07:20:21 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355903, encodeId=dc8a35590383, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Thu Dec 20 08:53:19 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355816, encodeId=a4f935581603, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Wed Dec 19 10:04:23 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355378, encodeId=9a423553e811, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Fri Dec 14 08:18:53 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355275, encodeId=8c0b3552e56a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Thu Dec 13 07:09:25 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355178, encodeId=dfaa3551e84c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Wed Dec 12 06:55:32 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355068, encodeId=49ae355068ed, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Tue Dec 11 07:11:24 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354976, encodeId=9a613549e68f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Mon Dec 10 07:17:00 CST 2018, time=2018-12-10, status=1, ipAttribution=)]
    2018-12-13 apple57298871

    学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1699745, encodeId=86091699e450c, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Sat Mar 30 09:23:00 CST 2019, time=2019-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356250, encodeId=1dd33562504e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Mon Dec 24 07:14:13 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356070, encodeId=10103560e0ec, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Sat Dec 22 07:20:21 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355903, encodeId=dc8a35590383, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Thu Dec 20 08:53:19 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355816, encodeId=a4f935581603, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Wed Dec 19 10:04:23 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355378, encodeId=9a423553e811, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Fri Dec 14 08:18:53 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355275, encodeId=8c0b3552e56a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Thu Dec 13 07:09:25 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355178, encodeId=dfaa3551e84c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Wed Dec 12 06:55:32 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355068, encodeId=49ae355068ed, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Tue Dec 11 07:11:24 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354976, encodeId=9a613549e68f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Mon Dec 10 07:17:00 CST 2018, time=2018-12-10, status=1, ipAttribution=)]
    2018-12-12 apple57298871

    学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1699745, encodeId=86091699e450c, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Sat Mar 30 09:23:00 CST 2019, time=2019-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356250, encodeId=1dd33562504e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Mon Dec 24 07:14:13 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356070, encodeId=10103560e0ec, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Sat Dec 22 07:20:21 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355903, encodeId=dc8a35590383, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Thu Dec 20 08:53:19 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355816, encodeId=a4f935581603, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Wed Dec 19 10:04:23 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355378, encodeId=9a423553e811, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Fri Dec 14 08:18:53 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355275, encodeId=8c0b3552e56a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Thu Dec 13 07:09:25 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355178, encodeId=dfaa3551e84c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Wed Dec 12 06:55:32 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355068, encodeId=49ae355068ed, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Tue Dec 11 07:11:24 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354976, encodeId=9a613549e68f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Mon Dec 10 07:17:00 CST 2018, time=2018-12-10, status=1, ipAttribution=)]
    2018-12-11 apple57298871

    学习了

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1699745, encodeId=86091699e450c, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Sat Mar 30 09:23:00 CST 2019, time=2019-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356250, encodeId=1dd33562504e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Mon Dec 24 07:14:13 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356070, encodeId=10103560e0ec, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Sat Dec 22 07:20:21 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355903, encodeId=dc8a35590383, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Thu Dec 20 08:53:19 CST 2018, time=2018-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355816, encodeId=a4f935581603, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Wed Dec 19 10:04:23 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355378, encodeId=9a423553e811, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Fri Dec 14 08:18:53 CST 2018, time=2018-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355275, encodeId=8c0b3552e56a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Thu Dec 13 07:09:25 CST 2018, time=2018-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355178, encodeId=dfaa3551e84c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Wed Dec 12 06:55:32 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355068, encodeId=49ae355068ed, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Tue Dec 11 07:11:24 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=354976, encodeId=9a613549e68f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=970d1684898, createdName=apple57298871, createdTime=Mon Dec 10 07:17:00 CST 2018, time=2018-12-10, status=1, ipAttribution=)]
    2018-12-10 apple57298871

    学习了

    0

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