JAHA:外周动脉疾病与房颤发生之间的相关性!

2018-04-17 xing.T MedSci原创

由此可见,较低ABI诊断的外周动脉疾病,包括边界性ABI,是房颤一个较弱的危险因素。ABI>1.4与房颤风险增加无关。外周动脉疾病与房颤之间的关系主要是由传统的动脉粥样硬化危险因素来解释。

虽然通过踝肱指数(ABI)定义的外周动脉疾病与房颤事件相关,但是边界性ABI(0.90-1)或不可压缩动脉(>1.4)患者的房颤风险尚不明确。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在通过以人群为基础的前瞻性队列研究-ARIC(社区动脉粥样硬化风险)研究来评估边界性ABI和ABI>1.4与房颤之间的相关性。

研究人员纳入了14794名(年龄为54.2±5.8岁,55%为女性,26%为黑人)测量了基础(1987–1989)ABI且无房颤的受试者,研究人员通过病例、死亡证明和心电图来确诊房颤。通过使用COX比例风险,研究人员评估了ABI与AF之间的关系。

在中位随访23.3年期间,共有2288例房颤患者。在调整心血管危险因素后,ABI<1.0个体相比于ABI为1-1.4的患者发生房颤的风险比(HR)(95%可信区间)为1.13(1.01-1.27)。ABI>1.4与房颤风险增加无关。ABI≤0.9和边界性ABI与较高的房颤风险相关,相比于ABI为1-1.4的个体。人口统计学调整后的HRs(95%可信区间)分别为1.43(1.17-1.75)和1.32(1.16–1.50)。然而,ABI≤0.9和边界性ABI与房颤之间的相关性在调整心血管危险因素后有所减弱(HR [95%CI]分别为1.1[0.90-1.34 ]和1.14[1.0-1.30])。

由此可见,较低ABI诊断的外周动脉疾病,包括边界性ABI,是房颤一个较弱的危险因素。ABI>1.4与房颤风险增加无关。外周动脉疾病与房颤之间的关系主要是由传统的动脉粥样硬化危险因素来解释。

原始出处:

Wobo Bekwelem,et al. Association of Peripheral Artery Disease With Incident Atrial Fibrillation: The ARIC (Atherosclerosis Risk in Communities) Study, JAHA.2018. https://doi.org/10.1161/JAHA.117.007452

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    2018-04-19 zhaohui6731
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