AHA2019:RECOVERY研究:无症状重度主动脉瓣狭窄患者,早期手术改善生存达8年

2019-11-18 国际循环编辑部 国际循环

目前,有关无症状重度主动脉瓣狭窄患者手术干预的最佳时机仍存争议,AHA 2019最新临床研究专场,Duk-Hyun Kang公布的RECOVERY研究显示,无症状重度主动脉瓣狭窄患者早期手术治疗与观察组相比,可改善生存期达8年。

目前,有关无症状重度主动脉瓣狭窄患者手术干预的最佳时机仍存争议,AHA 2019最新临床研究专场,Duk-Hyun Kang公布的RECOVERY研究显示,无症状重度主动脉瓣狭窄患者早期手术治疗与观察组相比,可改善生存期达8年。

RECOVERY研究的目的是评估无症状重度主动脉瓣狭窄患者的手术治疗与观察治疗的安全性和获益。
 
研究者将符合入选标准的无症状重度主动脉瓣狭窄患者以1:1开放标签的方式随机分配至早期手术主动脉瓣置换(AVR)组(n=4089)或观察组(n=4090)。随访6.2年。主要研究终点为手术死亡,心血管死亡;次要终点为全因死亡,再次主动脉瓣手术,临床血栓事件和心力衰竭住院。
 
纳入标准:年龄20~80岁;重度主动脉瓣狭窄(主动脉瓣面积AVA 0.75 cm2,峰值速度≥4.5 m/s,或平均梯度≥50 mm Hg);无症状。排除标准:运动性呼吸困难、晕厥、晕厥前兆或心绞痛;左心室射血分数(LVEF)<50%;具有临床意义的主动脉返流或二尖瓣病变;既往心脏手术;心脏负荷测试阳性;癌症等。
 
其他特征/特性:体重指数(BMI)24.5 kg/m2;冠状动脉疾病4%~5%;EuroSCORE II平均值0.9%;主动脉瓣狭窄的病因60%为双尖瓣,33%为退行性变,6%为风湿性疾病;峰值速度5.1 m /s,平均梯度64 mm Hg,AVA 0.64  cm2;平均LVEF为65%。


 
主要终点结果,随访4年,手术死亡率或心血管死亡率,早期手术组低于观察组(1.4% vs. 5.7%,P<0.05);8年时,早期手术组更低(1.4% vs. 25.5%,P=0.003)。次要终点结果,与观察组相比,早期手术组的8年全因死亡率(31.8% vs. 10.2%,P<0.05)和心力衰竭住院率(11% vs. 0%,P<0.05)均较低;观察组中的任何次要终点或AVR,4年时为62%,8年时为92%。
 
该研究结果表明,在无症状重度主动脉瓣狭窄(AVA 0.75  cm2,平均梯度≥50 mm Hg,峰值速度≥4.5 m/s)的患者中进行早期手术治疗与观察组相比,可提高至8年的生存率。目前,无症状主动脉瓣狭窄手术在美国心脏协会/美国心脏病学学会瓣膜性心脏病指南中为IIb类适应证。另有观察数据表明,峰值速度> 5 m/s的患者受益更多,尤其是低手术风险的患者。
 
值得注意的是,研究中患者的手术风险较低,即手术死亡率为零,这可能与经验丰富的术者/医疗机构有关。此外,有趣的是,尽管主动脉瓣重度狭窄,但观察组患者仍可改善生存长达8年(仅2例交叉至手术组)。有研究表明,该“潜伏期”(即出现重度主动脉狭窄且无症状)约为1~2年,此研究队列中的二尖瓣主动脉瓣狭窄患者比例较高,这可能是部分原因。另外,运动测试只是有选择地进行,因此,有一部分患者会出现“隐匿”的症状性主动脉瓣狭窄,而负荷测试可掩盖该症状。

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1783705, encodeId=3b6b1e8370573, content=<a href='/topic/show?id=d195513038' target=_blank style='color:#2F92EE;'>#cover#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5130, encryptionId=d195513038, topicName=cover)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Sun Mar 08 22:35:00 CST 2020, time=2020-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1993160, encodeId=2d721993160e6, content=<a href='/topic/show?id=04801524457' target=_blank style='color:#2F92EE;'>#Recovery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15244, encryptionId=04801524457, topicName=Recovery)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Tue Dec 31 17:35:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1774591, encodeId=37ba1e74591c1, content=<a href='/topic/show?id=a64f95e9906' target=_blank style='color:#2F92EE;'>#重度主动脉瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95799, encryptionId=a64f95e9906, topicName=重度主动脉瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=773e38606601, createdName=lxg964, createdTime=Wed Jan 29 10:35:00 CST 2020, time=2020-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268202, encodeId=bacd126820259, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332672, encodeId=b4aa13326e29f, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415568, encodeId=c6711415568a5, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485047, encodeId=3bba148504ef8, content=<a href='/topic/show?id=4bbe5902ed2' target=_blank style='color:#2F92EE;'>#无症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59027, encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=)]
    2020-03-08 yahu
  2. [GetPortalCommentsPageByObjectIdResponse(id=1783705, encodeId=3b6b1e8370573, content=<a href='/topic/show?id=d195513038' target=_blank style='color:#2F92EE;'>#cover#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5130, encryptionId=d195513038, topicName=cover)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Sun Mar 08 22:35:00 CST 2020, time=2020-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1993160, encodeId=2d721993160e6, content=<a href='/topic/show?id=04801524457' target=_blank style='color:#2F92EE;'>#Recovery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15244, encryptionId=04801524457, topicName=Recovery)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Tue Dec 31 17:35:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1774591, encodeId=37ba1e74591c1, content=<a href='/topic/show?id=a64f95e9906' target=_blank style='color:#2F92EE;'>#重度主动脉瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95799, encryptionId=a64f95e9906, topicName=重度主动脉瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=773e38606601, createdName=lxg964, createdTime=Wed Jan 29 10:35:00 CST 2020, time=2020-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268202, encodeId=bacd126820259, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332672, encodeId=b4aa13326e29f, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415568, encodeId=c6711415568a5, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485047, encodeId=3bba148504ef8, content=<a href='/topic/show?id=4bbe5902ed2' target=_blank style='color:#2F92EE;'>#无症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59027, encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1783705, encodeId=3b6b1e8370573, content=<a href='/topic/show?id=d195513038' target=_blank style='color:#2F92EE;'>#cover#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5130, encryptionId=d195513038, topicName=cover)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Sun Mar 08 22:35:00 CST 2020, time=2020-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1993160, encodeId=2d721993160e6, content=<a href='/topic/show?id=04801524457' target=_blank style='color:#2F92EE;'>#Recovery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15244, encryptionId=04801524457, topicName=Recovery)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Tue Dec 31 17:35:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1774591, encodeId=37ba1e74591c1, content=<a href='/topic/show?id=a64f95e9906' target=_blank style='color:#2F92EE;'>#重度主动脉瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95799, encryptionId=a64f95e9906, topicName=重度主动脉瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=773e38606601, createdName=lxg964, createdTime=Wed Jan 29 10:35:00 CST 2020, time=2020-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268202, encodeId=bacd126820259, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332672, encodeId=b4aa13326e29f, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415568, encodeId=c6711415568a5, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485047, encodeId=3bba148504ef8, content=<a href='/topic/show?id=4bbe5902ed2' target=_blank style='color:#2F92EE;'>#无症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59027, encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1783705, encodeId=3b6b1e8370573, content=<a href='/topic/show?id=d195513038' target=_blank style='color:#2F92EE;'>#cover#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5130, encryptionId=d195513038, topicName=cover)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Sun Mar 08 22:35:00 CST 2020, time=2020-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1993160, encodeId=2d721993160e6, content=<a href='/topic/show?id=04801524457' target=_blank style='color:#2F92EE;'>#Recovery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15244, encryptionId=04801524457, topicName=Recovery)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Tue Dec 31 17:35:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1774591, encodeId=37ba1e74591c1, content=<a href='/topic/show?id=a64f95e9906' target=_blank style='color:#2F92EE;'>#重度主动脉瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95799, encryptionId=a64f95e9906, topicName=重度主动脉瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=773e38606601, createdName=lxg964, createdTime=Wed Jan 29 10:35:00 CST 2020, time=2020-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268202, encodeId=bacd126820259, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332672, encodeId=b4aa13326e29f, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415568, encodeId=c6711415568a5, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485047, encodeId=3bba148504ef8, content=<a href='/topic/show?id=4bbe5902ed2' target=_blank style='color:#2F92EE;'>#无症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59027, encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=)]
    2019-11-20 zhaohui6731
  5. [GetPortalCommentsPageByObjectIdResponse(id=1783705, encodeId=3b6b1e8370573, content=<a href='/topic/show?id=d195513038' target=_blank style='color:#2F92EE;'>#cover#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5130, encryptionId=d195513038, topicName=cover)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Sun Mar 08 22:35:00 CST 2020, time=2020-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1993160, encodeId=2d721993160e6, content=<a href='/topic/show?id=04801524457' target=_blank style='color:#2F92EE;'>#Recovery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15244, encryptionId=04801524457, topicName=Recovery)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Tue Dec 31 17:35:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1774591, encodeId=37ba1e74591c1, content=<a href='/topic/show?id=a64f95e9906' target=_blank style='color:#2F92EE;'>#重度主动脉瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95799, encryptionId=a64f95e9906, topicName=重度主动脉瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=773e38606601, createdName=lxg964, createdTime=Wed Jan 29 10:35:00 CST 2020, time=2020-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268202, encodeId=bacd126820259, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332672, encodeId=b4aa13326e29f, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415568, encodeId=c6711415568a5, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485047, encodeId=3bba148504ef8, content=<a href='/topic/show?id=4bbe5902ed2' target=_blank style='color:#2F92EE;'>#无症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59027, encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1783705, encodeId=3b6b1e8370573, content=<a href='/topic/show?id=d195513038' target=_blank style='color:#2F92EE;'>#cover#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5130, encryptionId=d195513038, topicName=cover)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Sun Mar 08 22:35:00 CST 2020, time=2020-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1993160, encodeId=2d721993160e6, content=<a href='/topic/show?id=04801524457' target=_blank style='color:#2F92EE;'>#Recovery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15244, encryptionId=04801524457, topicName=Recovery)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Tue Dec 31 17:35:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1774591, encodeId=37ba1e74591c1, content=<a href='/topic/show?id=a64f95e9906' target=_blank style='color:#2F92EE;'>#重度主动脉瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95799, encryptionId=a64f95e9906, topicName=重度主动脉瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=773e38606601, createdName=lxg964, createdTime=Wed Jan 29 10:35:00 CST 2020, time=2020-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268202, encodeId=bacd126820259, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332672, encodeId=b4aa13326e29f, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415568, encodeId=c6711415568a5, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485047, encodeId=3bba148504ef8, content=<a href='/topic/show?id=4bbe5902ed2' target=_blank style='color:#2F92EE;'>#无症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59027, encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1783705, encodeId=3b6b1e8370573, content=<a href='/topic/show?id=d195513038' target=_blank style='color:#2F92EE;'>#cover#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5130, encryptionId=d195513038, topicName=cover)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Sun Mar 08 22:35:00 CST 2020, time=2020-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1993160, encodeId=2d721993160e6, content=<a href='/topic/show?id=04801524457' target=_blank style='color:#2F92EE;'>#Recovery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15244, encryptionId=04801524457, topicName=Recovery)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Tue Dec 31 17:35:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1774591, encodeId=37ba1e74591c1, content=<a href='/topic/show?id=a64f95e9906' target=_blank style='color:#2F92EE;'>#重度主动脉瓣狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95799, encryptionId=a64f95e9906, topicName=重度主动脉瓣狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=773e38606601, createdName=lxg964, createdTime=Wed Jan 29 10:35:00 CST 2020, time=2020-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268202, encodeId=bacd126820259, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332672, encodeId=b4aa13326e29f, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415568, encodeId=c6711415568a5, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1485047, encodeId=3bba148504ef8, content=<a href='/topic/show?id=4bbe5902ed2' target=_blank style='color:#2F92EE;'>#无症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59027, encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Wed Nov 20 12:35:00 CST 2019, time=2019-11-20, status=1, ipAttribution=)]

相关资讯

2019 AHA:阿斯利康的SGLT2抑制剂Farxiga在III期临床显示出显著的心力衰竭改善

阿斯利康(AstraZeneca)的新数据表明,与安慰剂相比,SGLT2抑制剂Farxiga(dapagliflozin)可以减轻恶化的心力衰竭(HF)(定义为住院、紧急就诊或因心血管事件致死)。

Circulation:Odyssey Outcomes研究全新分析结果:阿利西尤单抗可降低所有类型卒中风险且不增加出血性卒中风险

在AHA 2019大会上,PCSK9抑制剂相关研究结果再度成为心血管领域的热点。今天,J. Wouter Jukema等发布的Odyssey Outcomes研究结果的再次分析,再度更新了我们对动脉粥样硬化性脑血管疾病的认知。分析结果发现:LDL-C(低密度脂蛋白胆固醇)的降低与出血性卒中之间并无明显相关性;PCSK9抑制剂阿利西尤单抗可降低ACS患者所有类型卒中的风险,且不增加出血性卒中风险,该

美国心脏协会专家称,喝红酒与预防心脏病不是因果关系

你是否确定你在吃的东西是否有利于健康?吃还是抛弃? 近期,美国心脏协会指出,适量饮用红酒与心脏健康有一定关系,但并没有研究证实饮酒可预防心脏病。 南加州大学Robert Kloner教授表示,目前尚不清楚红酒与这种益处是否直接相关,也不知道是否有其他因素起作用。

时隔14年AHA再发声明,血压测量的这些误区,可别再犯了

高血压是诱发心脏病和卒中的重要危险因素,而准确测量血压对于诊断和管理高血压至关重要!作为患者,你会测血压吗?作为医务工作者,该如何更好地指导患者测量血压?

2019年美国心脏协会科学会议:Rilonacept治疗复发性心包炎的II期临床数据

Kiniksa制药公司报告了一项开放标签的II期临床试验的最终数据,结果显示,每周一次、皮下注射的重组融合蛋白rilonacept可阻断IL-1α和IL-1β信号传导。这些数据将在2019年美国心脏协会科学会议上展示。

AHA2019丨ERUPTION研究:减少无复流,优化STEMI患者心肌再灌注,专家亮出中国方案

2019年11月16~18日,在美国费城召开的美国心脏协会(AHA)2019年会上,复旦大学附属中山医院黄东教授汇报了ERUPTION研究结果,成为中国唯一入选的最新临床研究(Featured Clinical Trial),其结果受到与会专家的极大关注。