NEJM:甲减造成如此严重的脱发,你见过吗?

2018-10-08 医咖会 医咖会

患者,女,41岁,近几个月指甲发生变化,脱发日益严重超过两年,到内分泌科就诊。体检发现患者皮肤干燥,指甲增厚并变脆(图A),脱发明显且毛发粗糙(图B),甲状腺弥漫性重大。

患者,女,41岁,近几个月指甲发生变化,脱发日益严重超过两年,到内分泌科就诊。体检发现患者皮肤干燥,指甲增厚并变脆(图A),脱发明显且毛发粗糙(图B),甲状腺弥漫性重大。



实验室检查结果显示,促甲状腺激素水平明显增加,为30.5mIU/ml(参考范围,0.5-5.0),血清游离甲状腺素水平为0.4ng/dl(参考范围,0.9-1.7ng/dl)。

进一步检测发现,抗甲状腺球蛋白抗体水平为793IU/ml(参考值≤55),抗甲状腺过氧化物酶抗体水平为2439 IU/ml(参考值≤9)。超声检查显示弥漫性甲状腺肿,具有不均匀的内部回声。

患者被诊断为桥本氏甲状腺炎引起的甲状腺功能减退症。在指甲增厚变脆以及脱发的患者中,鉴别诊断应考虑到甲减,虽然这种极端的表现不太典型。

给予患者左甲状腺素治疗,5年后,指甲变化和脱发的问题得到解决(分别为图C和图D)。



原始出处:
Takafumi Taguchi, et al. Brittle Nails and Hair Loss in Hypothyroidism. N Engl J Med. Oct 2018.

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    2018-10-14 laoli

    学习了,谢谢分享!

    0

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    2018-10-14 186****0580(小山羊)

    学习了谢谢了

    0

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    2018-10-10 明月清辉

    谢谢分享,学习了

    0

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    2018-10-08 天地飞扬

    了解一下,谢谢分享!

    0

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