Neurology:日本社区痴呆症患病率、发病率与存活率的趋势分析!

2017-04-21 xing.T MedSci原创

AD的发病率增加和生存率提高可能是导致日本老年人AD患病率的急剧增加的原因。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在全面探讨日本老年人痴呆患病率、发病率和生存率的长期趋势。

研究人员分别在1985年、1992年、1998年、2005年和2012年在年龄大于65岁的日本社区居民中进行了5个横断面痴呆调查。同时,研究人员分别在1988年(n=803)和2002年(n=1231)组建了2个年龄大于65岁无痴呆的居民队列,并且分别随访了10年。

全因痴呆症和阿尔茨海默病(AD)的年龄标化患病率随时间而增加(全因痴呆症:在1985年为6.8%,在1992年为4.6%,在1998年为5.3%,在2005年为8.4%,在2012年为11.3%,趋势P<0.01;对于AD:各年份分别为1.5%,1.4%,2.4%,3.9%和7.2%,趋势P<0.01),而血管性痴呆(VAD)无明显长期变化(各年份分别为2.4%,1.6%,1.5%,2.4%和2.4%,趋势P=0.59)。年龄和性别调整后的全因痴呆以及AD的发病率从1988年的队列到2002年的队列有所增加(全因痴呆症:调整后的风险比[aHR]为1.68,95%可信区间[CI]为1.38-2.06;对于AD:aHR为2.07,95%CI为1.59-2.70,VAD:aHR为1.18,95%CI为0.83-1.69),但VAD发病率没有增加。全因痴呆和AD的5年生存率从1988年队列到2002年队列有所增加(全因痴呆:从47.3%到65.2%;AD:从50.7%到75.1%;所有P<0.01)。

AD的发病率增加和生存率提高可能是导致日本老年人AD患病率的急剧增加的原因。

原始出处:

Tomoyuki Ohara,et al. Trends in dementia prevalence, incidence, and survival rate in a Japanese community. Neurology. 2017. http://www.neurology.org/content/early/2017/04/19/WNL.0000000000003932.abstract

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    2017-08-12 yinhl1978
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294314, encodeId=d33712943144b, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sat Apr 22 15:08:00 CST 2017, time=2017-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250457, encodeId=bcb9125045e4c, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Apr 22 15:08:00 CST 2017, time=2017-04-22, status=1, ipAttribution=)]
  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294314, encodeId=d33712943144b, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sat Apr 22 15:08:00 CST 2017, time=2017-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250457, encodeId=bcb9125045e4c, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Apr 22 15:08:00 CST 2017, time=2017-04-22, status=1, ipAttribution=)]
  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294314, encodeId=d33712943144b, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sat Apr 22 15:08:00 CST 2017, time=2017-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250457, encodeId=bcb9125045e4c, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Apr 22 15:08:00 CST 2017, time=2017-04-22, status=1, ipAttribution=)]
    2017-04-28 葫芦糊涂

    哦哦哦亏弄

    0

  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294314, encodeId=d33712943144b, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sat Apr 22 15:08:00 CST 2017, time=2017-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250457, encodeId=bcb9125045e4c, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Apr 22 15:08:00 CST 2017, time=2017-04-22, status=1, ipAttribution=)]
    2017-04-26 葫芦糊涂

    了啊怕热热吧area

    0

  8. 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createdBy=f49517, createdName=xinmeili, createdTime=Sat Apr 22 15:08:00 CST 2017, time=2017-04-22, status=1, ipAttribution=)]
    2017-04-25 葫芦糊涂

    弄了路上爸爸啊

    0

  9. 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