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Cell Reports：少量的压力有利于细胞健康和长寿

2017-11-09 小通 生物通

压力细胞健康长寿
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11月7日发表在《Cell Reports》的一篇文章介绍，西北大学研究学者认为线粒体压力有助于提高细胞恢复力，能预防细胞老化，延缓疾病风险。

11月7日发表在《Cell Reports》的一篇文章介绍，西北大学研究学者认为线粒体压力有助于提高细胞恢复力，能预防细胞老化，延缓疾病风险。人体由无数细胞组成，什么样的细胞与机体健康长寿有关呢？西北大学分子生物学家Richard I. Morimoto课题组发现小压力可以让细胞保持良好健康。这项发现将有助于科学家们逐渐解开衰老和退行性疾病之谜。“我们的最终目标不是试图让人活得更长，而是在细胞和分子水平上增加健康，从而使人在有效寿命期健康地活着，”Morimoto说。在围绕秀丽隐杆线虫的遗传学研究中，科学家们发现轻微受压的线粒体发出的信号能阻止细胞质蛋白质折叠质量监控系统随年龄增长的失效。反过来，错误蛋白积累在退行性疾病（如阿尔兹海默症、帕金森症等）中相当常见。“长期以来，人们一直认为线粒体长时间承压不好。但是我们的发现颠覆了传统。当你对线粒体施加一点压力时，线粒体释放的压力信号实际上细胞和动物的生存策略，它们能使动物变得更加抗压，寿命也像施了魔法一样被延长了。”有关生物老化研究，科学家们发现许多已被鉴定的组分在所有动物中都是保守的，因此秀丽隐杆线虫是研究衰老和衰老相关人类疾病的理想模

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    2018-02-23 zhaozhouchifen

    #Cell#

    0

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    2018-02-16 维他命

    #CEL#

    0

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Thu Nov 09 07:22:49 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-10 haige

    很有意的研究.

    0

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Thu Nov 09 07:22:49 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-10 186****0580(小山羊）

    学习了谢谢了

    0

  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Thu Nov 09 07:22:49 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-10 chunjianf

    学习了.谢谢分享

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Thu Nov 09 07:22:49 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-10 曾超军

    棒

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Thu Nov 09 07:22:49 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-09 happsf

    好好学习

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Thu Nov 09 07:22:49 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-09 明月清辉

    谢谢分享.学习了

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Thu Nov 09 07:22:49 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-09 榄枷檬

    谢谢分享

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Thu Nov 09 07:22:49 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-09 榄枷檬

    学习学习

    0

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根据一个新的佐治亚大学的研究，同性关系的人们在决定是否在工作中披露自己的性取向时，会面临相当大的焦虑，这会影响到他们的家庭生活。

压力之害堪比垃圾食品：高脂食物带来焦虑

压力，是现代生活的一种常态。而近期中美学者发表在ScientificReports的一项研究提示，压力的危害堪比垃圾食品。 这项研究发现，那些暴露在压力中的雌鼠，其与消化和代谢密切相关的肠道菌群的改变与进食高脂食物一样。 “我们有时候会认为压力是一种纯粹的心理现象，但事实上它可以确确实实导致身体的变化。”研究者说。 在这项研究中，研究者用的是8周龄的小鼠，其一半雌鼠和

Nat Commun:Nature子刊 压力会让大脑基因的表观遗传发生改变

近日，Nature Communications杂志上的一项研究发表了一种此前在动物机体中功能尚未明确的DNA修饰：A（腺嘌呤）甲基化。研究人员认为，在压力条件下大脑似乎更容易出现这种腺嘌呤甲基化，并且可能在神经精神疾病中扮演者重要角色。

Sci Rep：女同胞们请注意！压力对健康的影响，类似于垃圾食品

日常生活中，女性往往承担着更高的焦虑和抑郁概率，这与压力有关。最新一篇由中外团队联合完成的研究表明，压力会改变雌性小鼠肠道菌群的结构和组成，且影响力等同于垃圾食品。

Sci Rep：肠道菌群变化可能使女性变胖！

我们都知道不良的饮食习惯会对健康产生危害，但一项最新发现，压力也可以以不良饮食的方式对我们的身体造成不良影响。

BMC Cancer：压力大？注意前列腺健康！

前列腺癌是全世界导致死亡的一种主要疾病，并且大量的努力正在进行，来破译前列腺癌特异的细胞学和分子通路。长期不断的压力可以抑制生殖功能并且在集中癌症模型中可以促进肿瘤恶化，但是人们对对压力通过什么机制来导致癌症的发展和恶化的理解还不完善。因此，最近有研究人员在大鼠前列腺中，调查了压力、促性腺激素释放激素调节（GnRH）和癌症相关基因表达变化的关系。研究人员将成年雄性小鼠剧烈地或者重复性地暴露在拘束应