Gastroenterology:囊性纤维化结直肠癌筛查共识指南

2018-01-02 zhangfan MedSci原创

本指南旨在指导囊性纤维化患者、家属、医生以及相关人员进行相应的结肠癌风险筛查,该指南特异性针对囊性纤维化患者,与一般人群关于筛查起始年龄、筛查方法、准备和重复筛查和监测间隔时间的指导原则有所不同

治疗方法的进步大大提高了囊性纤维化(CF)患者的存活率,统计发现成年CF患者的结肠癌风险较一般人群高5-10倍,而接受器官移植后CF患者的结肠癌风险将提升25-30倍,考虑到这种情况,CF患者的结肠癌筛查十分关键。

近日多方参与的CF基金会针对CF患者的癌症风险、移植、治疗以及干预方法开展讨论,依据最新的研究成果制定了CF专家指南。会议检索了1159篇相关研究文章,对123篇进行系统分析后得出本次指南建议。

指南基于共同的,个性化治疗策略以及特定的胃肠道病情提出10项CRC筛检建议,以结肠镜检查为首选筛查方法,40岁开始,5年后进行复查,之后采取每3年的筛查间隔并进行CF特异性强化肠准备。对于接受器官移植的CF患者,由于免疫抑制有关的结肠癌风险,筛查应提前至30岁或移植后2年内进行。

本指南旨在指导囊性纤维化患者、家属、医生以及相关人员进行相应的结肠癌风险筛查,该指南特异性针对囊性纤维化患者,与一般人群关于筛查起始年龄、筛查方法、准备和重复筛查和监测间隔时间的指导原则有所不同。

原始出处:

Denis Hadjiliadis et al. Cystic Fibrosis Colorectal Cancer Screening Consensus Recommendations. Gastroenterology. December 28, 2017.

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    2018-02-11 许安
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    2018-09-23 wolongzxh
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    2018-01-10 liuweigang

    学习.了解了解

    0

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    2018-01-02 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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    2018-01-02 139****0239

    henhao

    0

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这些数据表明SPX-101促进ENaC膜浓度持续减低,导致粘液运输显著改善。

JCEM:维生素D对于成人囊性纤维化患者肠道菌群的影响

众多周知肠道菌群紊乱可能会加重囊性纤维化(CF)的严重程度,而维生素D缺乏又是CF患者常见的共发病,可能会影响肠道菌群的组成。近日在JCEM上发表的一篇文章则比较了维生素D充足和不足的CF患者的菌群,并评估了每周高剂量维生素D3的补充方案对于维生素D缺乏(25(OH)D<30ng/ml)的CF患者的肠道和呼吸道微生物的影响。

Eur Respir J:慢性感染铜绿假单胞菌患者囊性纤维化痰细胞的蛋白质组学研究

这些发现扩大了研究人员对CF肺疾病发病机制的认识,并确定痰液细胞蛋白具有潜在的作为疾病状态/预后的指标,以及具有作为治疗处方或治疗目标的分层决定因素的潜力。

Free RadicBiol Med:谷胱甘肽缺乏会加重囊性纤维化疾病引起的支气管损害

CF(囊性纤维化)是一种侵犯多脏器的遗传性疾病。主要表现为外分泌腺的功能紊乱、粘液腺增生、分泌液粘稠、汗液氯化钠含量增高。临床上有肺脏、气道、胰腺、肠道、胆道、输精管、子宫颈等的腺管被粘稠分泌物堵塞所引起一系列症状,而以呼吸系统损害最为突出。