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Viruses：噬菌体细胞内溶素和多糖解聚酶联合处理协同去除静态和动态金黄色葡萄球菌生物膜

2018-10-15 MedSci MedSci原创

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金黄色葡萄球菌是一种主要的病原体和生物膜制造者。生物膜可在诊所和食品生产中引起问题，并且对抗生素和消毒剂非常顽固。噬菌体内溶素通过降解细胞壁来杀死细菌，因此被认为是有前途的抗菌剂和抗生物膜剂。既往研究提出靶向细胞外基质中的多糖的解聚酶作为根除生物膜的多酶方法的一部分。且已经证明了细胞内溶素和解聚酶对静态模型中金黄色葡萄球菌生物膜的功效。然而，缺乏研究评估其在更现实条件下生长的生物膜的活性。

金黄色葡萄球菌是一种主要的病原体和生物膜制造者。生物膜可在诊所和食品生产中引起问题，并且对抗生素和消毒剂非常顽固。噬菌体内溶素通过降解细胞壁来杀死细菌，因此被认为是有前途的抗菌剂和抗生物膜剂。既往研究提出靶向细胞外基质中的多糖的解聚酶作为根除生物膜的多酶方法的一部分。且已经证明了细胞内溶素和解聚酶对静态模型中金黄色葡萄球菌生物膜的功效。然而，缺乏研究评估其在更现实条件下生长的生物膜的活性。

在这里，我们研究了细胞内溶素LysK和聚-N-乙酰葡糖胺解聚酶DA7在静态和动态（基于流动细胞的）模型中对葡萄球菌生物膜的功效。LysK显示出对多种金黄色葡萄球菌菌株的活性，并且LysK和DA7分别以低微摩尔浓度和纳摩尔浓度从聚苯乙烯和玻璃表面除去静态和动态生物膜。组合使用时，酶起协同作用，如静态生物膜的结晶紫染色所证明的，与动态模型中的单个酶处理和共聚焦激光扫描显微镜相比，可明显降低活细胞计数。

总体而言，该结果表明LysK和DA7是有效的抗生物膜剂，无论是单独还是组合使用。

原始出处：

Nanna M. C. Olsen, Elowine Thiran, et al., Synergistic Removal of Static and Dynamic Staphylococcus aureus Biofilms by Combined Treatment with a Bacteriophage Endolysin and a Polysaccharide Depolymerase. Viruses. 2018 Aug; 10(8): 438.

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    2019-04-19 仁医06

    #细胞内溶素#

    0

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    2018-10-17 jambiya

    #金黄色葡萄球菌#

    0

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    2018-10-17 ms1692810954239974

    #噬菌体#

    0

  4. 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14:39:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569745, encodeId=f7eb1569e45d1, content=<a href='/topic/show?id=49e0161680c' target=_blank style='color:#2F92EE;'>#SES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16168, encryptionId=49e0161680c, topicName=SES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fc215562628, createdName=dongjia2015, createdTime=Wed Oct 17 14:39:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596907, encodeId=31ce159690ea3, content=<a href='/topic/show?id=a3e68823477' target=_blank style='color:#2F92EE;'>#葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88234, encryptionId=a3e68823477, topicName=葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e618440395, createdName=手留余香, createdTime=Wed Oct 17 14:39:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349496, encodeId=03d834949639, content=好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 16 07:55:26 CST 2018, time=2018-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349475, encodeId=000f3494e5ac, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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    2018-10-17 zhouqu_8

    #体细胞#

    0

  5. 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    2018-10-17 sunrural_42825361

    #virus#

    0

  6. 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14:39:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569745, encodeId=f7eb1569e45d1, content=<a href='/topic/show?id=49e0161680c' target=_blank style='color:#2F92EE;'>#SES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16168, encryptionId=49e0161680c, topicName=SES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fc215562628, createdName=dongjia2015, createdTime=Wed Oct 17 14:39:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596907, encodeId=31ce159690ea3, content=<a href='/topic/show?id=a3e68823477' target=_blank style='color:#2F92EE;'>#葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88234, encryptionId=a3e68823477, topicName=葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e618440395, createdName=手留余香, createdTime=Wed Oct 17 14:39:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349496, encodeId=03d834949639, content=好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 16 07:55:26 CST 2018, time=2018-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349475, encodeId=000f3494e5ac, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Oct 16 05:29:34 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
    2018-10-17 dongjia2015

    #SES#

    0

  7. 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14:39:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569745, encodeId=f7eb1569e45d1, content=<a href='/topic/show?id=49e0161680c' target=_blank style='color:#2F92EE;'>#SES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16168, encryptionId=49e0161680c, topicName=SES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fc215562628, createdName=dongjia2015, createdTime=Wed Oct 17 14:39:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596907, encodeId=31ce159690ea3, content=<a href='/topic/show?id=a3e68823477' target=_blank style='color:#2F92EE;'>#葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88234, encryptionId=a3e68823477, topicName=葡萄球菌)], 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authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Oct 16 05:29:34 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
    2018-10-17 手留余香

    #葡萄球菌#

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e618440395, createdName=手留余香, createdTime=Wed Oct 17 14:39:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349496, encodeId=03d834949639, content=好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 16 07:55:26 CST 2018, time=2018-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349475, encodeId=000f3494e5ac, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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    2018-10-16 ylzr123

    好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！

    0

  9. 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authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Oct 16 05:29:34 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
    2018-10-16 yjs木玉

    好好好好好好好好

    0