ATVB:糖尿病患者和无糖尿病患者颈动脉斑块的差异

2019-04-19 xing.T 网络

由此可见,与非糖尿病患者相比,有症状的糖尿病患者更容易出现钙化和富含脂质坏死核心的颈动脉斑块,这表明糖尿病患者可能会出现更严重的动脉粥样硬化疾病,这应该在临床治疗中加以考虑。

糖尿病与高风险的动脉粥样硬化斑块有关。近日,心血管领域权威杂志Arteriosclerosis, Thrombosis, and Vascular Biology上发表了一篇研究文章,该研究通过血管壁磁共振成像旨在比较中国糖尿病患者和非糖尿病患者颈动脉粥样硬化斑块的特征。

研究人员通过超声测定了从横断面、观察性、多中心CARE-II(中国动脉粥样硬化风险评估)研究中招募的前循环和颈动脉粥样硬化斑块中脑缺血症状的患者。所有患者均接受颈动脉磁共振成像。研究人员使用线性(连续变量)和Logistic回归(二元变量)比较糖尿病患者和非糖尿病患者颈动脉斑块的形态和组成特征。

在总共招募的584名患者中,有182名(31.2%)糖尿病患者。根据单变量分析,糖尿病患者的平均血管壁面积(33.7 vs. 31.1mm2; P=0.002)、最大血管壁厚度(3.2 vs. 2.8 mm; P<0.001)、平均血管壁面积指数(43.8% vs. 41.0%; P<0.001)显著增加,并且与非糖尿病患者相比,糖尿病患者的钙化(51.6% vs. 36.6%; P=0.001)、富含脂质的坏死核心(77.5% vs. 58.5%; P<0.001)和高风险斑块(29.7% vs. 19.9%; P=0.011)患病率显著增加。在调整临床特征后,钙化(P=0.018)和富含脂质的坏死核心(P=0.001)的差异仍然具有统计学意义。

由此可见,与非糖尿病患者相比,有症状的糖尿病患者更容易出现钙化和富含脂质坏死核心的颈动脉斑块,这表明糖尿病患者可能会出现更严重的动脉粥样硬化疾病,这应该在临床治疗中加以考虑。 

原始出处:

Xiao Gao,et al.Differences in Carotid Plaques Between Symptomatic Patients With and Without Diabetes Mellitus A CARE-II Study.ATVB.2019.https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.312682

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1977974, encodeId=71c519e7974d4, content=<a href='/topic/show?id=20411e958de' target=_blank style='color:#2F92EE;'>#TVB#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17958, encryptionId=20411e958de, topicName=TVB)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Sun Jan 26 13:53:00 CST 2020, time=2020-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843544, encodeId=19f0184354453, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Fri Jun 14 10:53:00 CST 2019, time=2019-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280780, encodeId=63381280e80f9, content=<a href='/topic/show?id=c6ba1005490e' target=_blank style='color:#2F92EE;'>#颈动脉斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100549, encryptionId=c6ba1005490e, topicName=颈动脉斑块)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7387164, createdName=zhangj7108, createdTime=Sun Apr 21 12:53:00 CST 2019, time=2019-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330118, encodeId=5551133011899, content=<a href='/topic/show?id=a91c5e92328' target=_blank style='color:#2F92EE;'>#斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57923, encryptionId=a91c5e92328, topicName=斑块)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sun Apr 21 12:53:00 CST 2019, time=2019-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474731, encodeId=559014e4731ef, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sun Apr 21 12:53:00 CST 2019, time=2019-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042393, encodeId=a37b104239357, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Apr 20 00:53:00 CST 2019, time=2019-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364914, encodeId=1e9f3649140c, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri Apr 19 22:07:43 CST 2019, time=2019-04-19, status=1, ipAttribution=)]
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    2019-04-20 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2019-04-19 一个字-牛

    学习了谢谢分享

    0

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