PLos One:系统性红斑狼疮中身体标志与精神健康的相关性:慢性自身免疫性疾病中痛苦的作用

2018-04-17 xiangting MedSci原创

这些结果揭示了狼疮的身体表现包括疲劳、疼痛、体重指数和焦虑以及身体和心理功能下降对抑郁的影响。

系统性红斑狼疮(SLE)是一种慢性自身免疫性疾病,世界范围内患者众多。焦虑、抑郁和疲劳是SLE的常见症状,会导致生活质量下降。这项研究调查了狼疮的身体和精神表现之间的相互作用。在一个SLE患者队列中进行了临床表现、实验室检查和心理指标之间的相关性分析。

使用一组仪器评估了72名狼疮患者的心理状态,包括疲劳评估(CFS和FSS)、抑郁(HADS)、焦虑(HADS)、整体健康(SF-36和PSQI)和亲密关系满意度(RAS&CSI)。这些评估得分与狼疮临床特征和实验室检查值进行相关分析。

以医院抑郁和焦虑量表衡量,SLE患者队列中抑郁的患病率为41.7%。该研究发现,疼痛(p=0.001),体重指数(p = 0.026),Chalder疲劳量表(p<0.001),疲劳严重程度量表(p<0.001)和焦虑(p=0.001)均与抑郁呈正相关。总补体(CH50)(p = 0.032)和SF-36身体和心理特征评估与抑郁呈负相关。纵向分析表明疾病相关性主诉脱发(p = 0.008)和关系评估量表评分(p = 0.004)也可能与SLE患者的抑郁相关。临床和心理社会特征的多变量考察确定了疲劳严重程度量表(p = 0.026),SF-36身体功能(p = 0.040),身体角色功能(0.030)和心理健康(p = 0.002)是与SLE队列抑郁直接相关的最佳指标。

这些结果揭示了狼疮的身体表现包括疲劳、疼痛、体重指数和焦虑以及身体和心理功能下降对抑郁的影响。疲劳是与队列中SLE患者抑郁相关的最强因素。身体和社会/心理方面都可能会导致狼疮的抑郁和焦虑。

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    2018-04-19 zhouqu_8
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