JACC:心肌应变性在心衰病人预后价值方面优于射血分数

2018-05-02 MedSci MedSci原创

目前,心衰的分级是根据患者的左室射血分数(LVEF)而定的,但其预后价值仍存在争议。心肌顺应性是独立于LVEF的一个心衰预后因素。本研究的目的旨在评估整体纵向应变(GLS)对心衰病人的预后价值。本研究纳入了4172名心衰病人,根据LVEF将其分成了LVEF减少组(LVEF <40%)、LVEF中等组(LVEF 40%-49%)和保留型LVEF组(LVEF ≥50%);同时,根据患者的GLS,

目前,心衰的分级是根据患者的左室射血分数(LVEF)而定的,但其预后价值仍存在争议。心肌顺应性是独立于LVEF的一个心衰预后因素。本研究的目的旨在评估整体纵向应变(GLS)对心衰病人的预后价值。本研究纳入了4172名心衰病人,根据LVEF将其分成了LVEF减少组(LVEF <40%)、LVEF中等组(LVEF 40%-49%)和保留型LVEF组(LVEF ≥50%);同时,根据患者的GLS,将其分成了顺应性轻度降低组(GLS >12.6%)、中度降低组(8.1% < GLS <12.5%)和重度降低组(GLS ≤8.0%),主要终点事件是5年后的全因死亡率。分析结果显示,有1740名(40.4%)患者在5年后出现了死亡。LVEF减少组患者的死亡率高于LVEF中等组和保留型LVEF组(41%, 38%和39%; p = 0.031),而顺应性轻度降低组患者的死亡率明显高于中度降低组和重度降低组(49%、38%和 34%; p < 0.001)。多变量分析后发现,GLS每增高1%,患者的死亡风险降低5%(p < 0.001)。研究结果显示,对于急性心衰病

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    2018-09-09 hbwxf
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    2018-05-04 huangdf
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    2018-05-02 戒馋,懒,贪

    谢谢分享学习了

    0

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