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Neurology：动脉瘤性蛛网膜下腔出血后癫痫相关的长期死亡分析！

2017-06-15 xing.T MedSci原创

SIA-SAH癫痫死亡
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由此可见，在SIA-SAH后的12个月幸存者中在长期随访中伴发癫痫与死亡风险增加相关。SIA-SAH幸存者需要长期精心随访，包括伴发癫痫的识别和有效的治疗以防止可以避免的死亡。

近日，神经病学领域权威取杂志Neurology上发表了一篇研究文章，研究人员旨在阐明囊形颅内动脉瘤导致的蛛网膜下腔出血（SIA-SAH）12个月幸存者癫痫相关的死亡原因以及随后的过量长期死亡率。

研究人员通过库奥皮奥SIA数据库纳入了所有的入住库奥皮奥大学医院的SIA-SAH患者。该研究队列由在1995年至2007年期间入院的779例患者组成，并且这些患者在SIA-SAH后幸存了12个月。研究人员从芬兰国家登记中心获得1994年至2014年期间这些患者所使用的补偿抗癫痫药物和死亡原因（ICD-10）。

该研究共有779例12个月存活者，随访至其死亡（n=197）或2014年12月31日，SIA-SAH后平均12年。SIA-SAH后有121例（15%）患者被确诊为癫痫，34/121（28%）死于随访结束时，7/34例（21%）患者以癫痫作为死亡的直接原因。SIA-SAH后12个月仍存活的779例患者中，癫痫是死亡的独立危险因素（风险比为1.8，95%可信区间为1.1-3）。

由此可见，在SIA-SAH后的12个月幸存者中在长期随访中伴发癫痫与死亡风险增加相关。SIA-SAH幸存者需要长期精心随访，包括伴发癫痫的识别和有效的治疗以防止可以避免的死亡。

原始出处：

Jukka Huttunen,et al. Epilepsy-associated long-term mortality after aneurysmal subarachnoid hemorrhage. Neurology. 2017.http://dx.doi.org/10.1212/WNL.0000000000004113

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    2018-04-16 aliceclz

    #蛛网膜#

    0

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    2018-02-11 yinhl1978

    #Neurol#

    0

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    2017-06-17 紫砂壶

    #动脉瘤性蛛网膜下腔出血#

    0

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    2017-06-16 dachengl

    数据库+良好的随访的贡献

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1654439, encodeId=74f8165443962, content=<a href='/topic/show?id=5ab788e81d3' target=_blank style='color:#2F92EE;'>#蛛网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88781, encryptionId=5ab788e81d3, topicName=蛛网膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=396c24497244, createdName=aliceclz, createdTime=Mon Apr 16 20:33:00 CST 2018, time=2018-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999985, encodeId=6eb2199998542, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Feb 11 01:33:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337795, encodeId=f7bb133e795ba, content=<a href='/topic/show?id=376c332e497' target=_blank style='color:#2F92EE;'>#动脉瘤性蛛网膜下腔出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33274, encryptionId=376c332e497, topicName=动脉瘤性蛛网膜下腔出血)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/UdV6ialcayj7Qv8RQm1mVfNYPKxjiaolxwglAZpCo6CwjTicOroW2Xb0Kxnc65viaxGpkuqHW7WzzbYgRLw3qooDoA/132, createdBy=04c22500137, createdName=紫砂壶, createdTime=Sat Jun 17 06:33:00 CST 2017, time=2017-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211546, encodeId=4db8211546a9, content=数据库+良好的随访的贡献, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4cd1660740, createdName=dachengl, createdTime=Fri Jun 16 12:45:59 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211377, encodeId=f1712113e75f, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Fri Jun 16 07:10:17 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211349, encodeId=95452113493b, content=好文章，值得拜读，受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Jun 16 06:42:42 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211197, encodeId=286c21119e36, content=学习了，受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jun 15 19:05:36 CST 2017, time=2017-06-15, status=1, ipAttribution=)]
    2017-06-16 meiliwuxian

    学习一下

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1654439, encodeId=74f8165443962, content=<a href='/topic/show?id=5ab788e81d3' target=_blank style='color:#2F92EE;'>#蛛网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88781, encryptionId=5ab788e81d3, topicName=蛛网膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=396c24497244, createdName=aliceclz, createdTime=Mon Apr 16 20:33:00 CST 2018, time=2018-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999985, encodeId=6eb2199998542, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Feb 11 01:33:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337795, encodeId=f7bb133e795ba, content=<a href='/topic/show?id=376c332e497' target=_blank style='color:#2F92EE;'>#动脉瘤性蛛网膜下腔出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33274, encryptionId=376c332e497, topicName=动脉瘤性蛛网膜下腔出血)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/UdV6ialcayj7Qv8RQm1mVfNYPKxjiaolxwglAZpCo6CwjTicOroW2Xb0Kxnc65viaxGpkuqHW7WzzbYgRLw3qooDoA/132, createdBy=04c22500137, createdName=紫砂壶, createdTime=Sat Jun 17 06:33:00 CST 2017, time=2017-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211546, encodeId=4db8211546a9, content=数据库+良好的随访的贡献, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4cd1660740, createdName=dachengl, createdTime=Fri Jun 16 12:45:59 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211377, encodeId=f1712113e75f, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Fri Jun 16 07:10:17 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211349, encodeId=95452113493b, content=好文章，值得拜读，受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Jun 16 06:42:42 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211197, encodeId=286c21119e36, content=学习了，受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jun 15 19:05:36 CST 2017, time=2017-06-15, status=1, ipAttribution=)]
    2017-06-16 1e10c84am36(暂无匿称)

    好文章，值得拜读，受益

    0

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    2017-06-15 虈亣靌

    学习了，受益匪浅。

    0