BMJ:中高强度有氧及力量训练对轻中度痴呆患者认知改善无益

2018-05-22 zhangfan MedSci原创

研究认为对于轻中度痴呆人群,中高强度的有氧和力量锻炼对患者的认知能力有轻微的损伤,但其与临床之间的关系尚不明确。体育锻炼可以改善痴呆人群的身体机能,但对于其他临床结果无显著的改善作用

近日研究人员考察了中高强度有氧和力量锻炼对轻中度痴呆患者认知障碍和其他临床结果的影响。

研究在英国15个社区医疗中心开展,494名痴呆患者参与,其中329人接受有氧和力量锻炼,165人接受常规治疗,锻炼组参与者在常规治疗基础上接受4个月的监督锻炼和持续性体育活动。研究的主要终点是12个月阿尔茨海默病认知评分变化(ADAS-cog),次要终点包括日常生活能力、神经精神症状、健康相关生活质量、护理人员负担以及身体素质(包括6分钟步行测试)。

参与者平均年龄77岁,男性占61%。12个月后,锻炼组参与者平均ADAS-cog得分上升至25.2,对照组为23.8,结果显示锻炼会加剧痴呆人群的认知损伤,但差异不显著且临床相关性尚不明确。组间次要终点差异不显著。锻炼组参与者依从性好,65%的参与者完成了3/4以上的锻炼指标,锻炼组参与者6分钟步行测试能力得到显著改善。

研究认为对于轻中度痴呆人群,中高强度的有氧和力量锻炼对患者的认知能力有轻微的损伤,但其与临床之间的关系尚不明确。体育锻炼可以改善痴呆人群的身体机能,但对于其他临床结果无显著的改善作用。

原始出处:


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    2019-04-24 gaoxiaoe
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    2018-05-27 周周人

    学习.

    0

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    2018-05-24 aids219
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    2018-05-23 baihao215

    有点惊讶啊.学习了

    0

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    2018-05-22 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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