J Gastroen Hepatol:肠易激综合征与功能性消化不良临床共性及差异研究

2017-09-10 zhangfan MedSci原创

研究发现,腹胀是功能性消化不良和肠易激综合征共同的疾病症状,餐后窘迫综合征患者易发展为肠易激综合征,尤其是便秘型肠易激综合征

功能性消化不良(FD)和肠易激综合征(IBS)相同的胃肠道症状谱、患病率或相关因素仍不清楚。近日研究人员就相关的临床人口统计学特征及其风险因素进行了研究。

研究在韩国开展,胃肠道门诊患者参与者研究。所有参与者的胃肠道症状至少在过去3个月内每周出现1次。功能性肠胃疾病的症状根据罗马III诊断标准,遗传多态性危险考察因素包括5-HTTLPR、ADRA2A 1291 G以及CCK-1R 内含子 779T>C。

研究招募了632名参与者,其中对照278人,FD患者308人,IBS患者156人,110人同时具有FD和IBS症状。研究发现FD-IBS双症状患者其症状严重程度较高,包括腹胀,恶心,呕吐,大便硬或块状,排便困难以及排便不完全感,并且抑郁评估得分较高。对于IBS患者,单身,离异或丧偶的婚姻状况、恶心、腹胀和排便后不完全排空是IBS-FD重叠的独立危险因素,而年轻、抑郁、腹胀和餐后窘迫综合征是FD患者IBS-FD重叠的独立危险因素。5-HTTLPR L/L是二者共同的遗传危险因素(OR: 12.47; 95% CI: 2.00–77.75; P = 0.007)。

研究发现,腹胀是功能性消化不良和肠易激综合征共同的疾病症状,餐后窘迫综合征患者易发展为肠易激综合征,尤其是便秘型肠易激综合征。

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    2017-10-10 许安
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    2017-09-12 gwc384
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    2017-09-12 zhouqu_8
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    2017-09-11 往日如昨

    学习了谢谢分享

    0

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    2017-09-10 186****0580(小山羊)

    学习了谢谢了

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    2017-09-10 Y—xianghai

    学习了新知识

    0

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