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Cell重磅发布：2018年十大更佳论文/综述出炉

2019-01-18 陈莫伊 生物探索

Cell最佳论文综述合集
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一年一度的Cell最佳系列终于出炉了。

一年一度的Cell最佳系列终于出炉了。



在“Best of Cell 2018”合集中，该杂志从2017年年底和2018年发表的文章中评出了8篇“最佳论文”以及2篇“最佳综述”。

这些研究主题涉及利用人工智能（AI）鉴别和诊断疾病、用最先进的技术克隆猴子等。

Cell杂志称，广泛的研究范围反应了生物医学正朝着令人兴奋的跨学科融合迈进。以下是入选论文和综述概要：

最佳论文①

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

一个国际研究小组证实，肠道微生物影响着大脑中关键的免疫细胞——小胶质细胞（microglia），且这种影响在雄性和雌性小鼠中显著不同。

最佳论文②

Identification of the Human Skeletal Stem Cell

来自美国斯坦福大学的科学家们首次鉴定出了人类骨骼干细胞。

最佳论文③

Pharmacogenomics of GPCR Drug Targets

一个国际研究小组在该论文中进一步研究了G蛋白偶联受体（GPCR，目前最主要的药物靶标）的突变。科学家们认为，这方面的研究将提高相关药物治疗的精准性。

最佳论文④

Physiological and Genetic Adaptations to Diving in Sea Nomads

这项研究证实，生活在菲律宾、马来西亚和印度尼西亚之间海域的、以潜水能力惊人著称的巴瑶族，可能发展出了适应潜水的专门基因，导致他们的脾脏比普通人大50%。

最佳论文⑤

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth:TRACERx Renal

来自Wellcome Trust Sanger研究所的科学家们鉴定出了导致肾癌的最早期的关键基因变化。让人惊讶的是，首个关键基因变化发生于儿童或青少年时期，四五十年后，部分由此产生的细胞会发展为肾癌。

最佳论文⑥

Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer

来自中国科学院上海神经科学研究所的科学家们第一次利用体细胞核移植技术成功克隆出两只猕猴——中中和华华。这一里程碑式研究填补了克隆灵长类动物长达20年的空白。

最佳论文⑦

Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity

来自香港科技大学的科学家们构建了一种神经突触研究分子平台，这将有助于深入了解神经元突触是如何形成的，以及其动态调节的机制。

最佳论文⑧

Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning

广州妇女儿童医疗中心、加州大学圣地亚哥分校眼科教授张康团队训练了一个基于“迁移学习”的全新AI诊断工具，可通过视网膜OCT（光学相干断层扫描）图像筛查致盲性视网膜疾病，并能在30秒内决定患者是否需要治疗，准确率可达95%以上。

最佳综述①

The Biology of CRISPR-Cas:Backward and Forward

CRISPR先驱Emmanuelle Charpentier等科学家在这篇综述中回顾了多种CRISPR-Cas系统的生物学特性，以及近年来在理解“CRISPR-Cas免疫力三个阶段潜在机制”方面获得的主要进展。同时，文章还讨论了该领域一些悬而未决的问题。

最佳综述②

Metazoan MicroRNAs

来自霍华德•休斯医学研究所的David P.Bartel在该综述中总结了与miRNAs生物起源、基因组学和进化等相关的新进展，以及调控miRNAs的相关研究。

写在最后

入选“Best of Cell 2018”的所有论文和综述均可点击 https://cell-bestof2018.elsevierdigitaledition.com/ 全文免费阅读。


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    2019-10-22 zhaozhouchifen

    #Cell#

    0

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    2019-11-01 维他命

    #CEL#

    0

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    2019-02-19 grain121

    科研知识增加

    0

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    2019-02-06 月影子说

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1871089, encodeId=bf4118e1089ae, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Oct 22 10:37:00 CST 2019, time=2019-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961366, encodeId=58cc19613664a, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Nov 01 06:37:00 CST 2019, time=2019-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=361045, encodeId=4faf361045f7, content=科研知识增加, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a3c2499533, createdName=grain121, createdTime=Tue Feb 19 21:49:17 CST 2019, time=2019-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360047, encodeId=855236004e37, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Wed Feb 06 11:20:03 CST 2019, time=2019-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359802, encodeId=2a3c359802ef, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Sat Feb 02 11:53:40 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359760, encodeId=341b359e605a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Fri Feb 01 20:04:44 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359638, encodeId=3b4b3596382c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Thu Jan 31 09:07:59 CST 2019, time=2019-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359598, encodeId=91763595980f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Wed Jan 30 14:36:18 CST 2019, time=2019-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359497, encodeId=252e35949e0e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Tue Jan 29 09:21:42 CST 2019, time=2019-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359420, encodeId=6c1b35942051, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Mon Jan 28 09:57:22 CST 2019, time=2019-01-28, status=1, ipAttribution=)]
    2019-02-02 月影子说

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1871089, encodeId=bf4118e1089ae, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Oct 22 10:37:00 CST 2019, time=2019-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961366, encodeId=58cc19613664a, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Fri Nov 01 06:37:00 CST 2019, time=2019-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=361045, encodeId=4faf361045f7, content=科研知识增加, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a3c2499533, createdName=grain121, createdTime=Tue Feb 19 21:49:17 CST 2019, time=2019-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360047, encodeId=855236004e37, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Wed Feb 06 11:20:03 CST 2019, time=2019-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359802, encodeId=2a3c359802ef, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Sat Feb 02 11:53:40 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359760, encodeId=341b359e605a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Fri Feb 01 20:04:44 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359638, encodeId=3b4b3596382c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Thu Jan 31 09:07:59 CST 2019, time=2019-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359598, encodeId=91763595980f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Wed Jan 30 14:36:18 CST 2019, time=2019-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359497, encodeId=252e35949e0e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Tue Jan 29 09:21:42 CST 2019, time=2019-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359420, encodeId=6c1b35942051, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2bd41982263, createdName=月影子说, createdTime=Mon Jan 28 09:57:22 CST 2019, time=2019-01-28, status=1, ipAttribution=)]
    2019-02-01 月影子说

    学习

    0

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    2019-01-31 月影子说

    学习

    0

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    2019-01-30 月影子说

    学习

    0

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    2019-01-29 月影子说

    学习

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    2019-01-28 月影子说

    学习

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