Sci Rep：鸟类雌激素竟是多种炎症的“克星”！

2017-09-03 Heather_z727 来宝网

美国大学神经科学教授主导的一项新研究指出，斑马雀大脑中会自然合成雌激素，这些雌激素可以对抗神经炎症，也有潜力对抗身体其他部分的炎症，此次研究在身体的神经内分泌和免疫系统之间的相互作用中找到线索。

美国大学神经科学教授主导的一项新研究指出，斑马雀大脑中会自然合成雌激素，这些雌激素可以对抗神经炎症，也有潜力对抗身体其他部分的炎症，此次研究在身体的神经内分泌和免疫系统之间的相互作用中找到线索。

尽管炎症是正常的免疫反应的一部分，但是在大脑中，太多的炎症会导致退化，在最糟糕的情况下，会导致死亡。人类和其他哺乳动物大脑中产生雌激素，但鸣鸟进化的快速方法却是利用雌激素调节创伤后大脑的炎症。研究人员将斑马雀带回了实验室，希望看到鸟儿如何应对日常感染，如流感。事实上，实验显示，大脑中雌激素的合成增加了身体其它部位的感染。这又是为什么呢？

研究人员在报告中指出，“可能是为了保护脆弱的大脑回路，防止大脑被感染或对抗慢性炎症。因为，一旦大脑中形成慢性炎症是很难控制的，而雌激素合成可以保护神经回路。”

在实验室中，研究人员模拟了感染的过程，一群斑马雀通过化学激活免疫系统，模拟细菌感染。鸟类的对照组注射生理盐水，两小时内，注射了细菌的鸟类出现了经典的免疫反应，和疾病症状，如无精打采，发烧和食欲不振。24小时后，病禽的大脑出现高浓度的雌激素，两种类型的大脑细胞合成雌激素，分别是神经元和星形胶质细胞。为保护大脑不受影响增加了战斗力。弄清楚这些自然过程为研究铺平了道路，研究人员可以据此找出应对人类大脑变性和炎症的潜在治疗方法，如中风，阿尔茨海默氏症和帕金森氏症的。

原始出处：Alyssa L. Pedersen , Cassie J. Gould , Colin J. Saldanha. Activation of the peripheral immune system regulates neuronal aromatase in the adult zebra finch brain, Scientific Reports (2017).

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2017-09-04 wxl882001

学习一下

61 0
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2017-09-04 大爰

学习并分享!!

61 0
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2017-09-04 明月清辉

谢谢分享.学习了

1 0
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2017-09-04 杨利洪

学习了分享了

61 0
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2017-09-04 榄枷檬

谢谢分享

60 0
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2017-09-04 飛歌

厉害了很有用

18 0
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2017-09-04 cherry bomb

学习了谢谢分享

22 0
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2017-09-04 李东泽

很好.学习了.很有帮助.

15 0
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2017-09-04 天地飞扬

谢谢分享!

19 0
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likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 04 06:47:09 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240221, encodeId=9d5a24022129, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Sep 04 06:35:40 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240214, encodeId=f2ca2402149d, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Mon Sep 04 06:23:03 CST 2017, time=2017-09-04, status=1, ipAttribution=)]
2017-09-04 189****1577

值得推荐一下

21 0