JCEM:先前低血糖对后续低血糖有何影响?

2017-08-04 xuyihan MedSci原创

大家都知道急性低血糖会加速胃排空和增加心脏收缩力。然而,先前的低血糖会对后续低血糖的激素反应产生何作用呢?为了确定健康人群中先前低血糖对后续低血糖产生的胃和心脏的影响,Palash Kar等人进行了一项前瞻性、单盲、随机、交叉研究。

大家都知道急性低血糖会加速胃排空和增加心脏收缩力。然而,先前的低血糖会对后续低血糖的激素反应产生何作用呢?为了确定健康人群中先前低血糖对后续低血糖产生的胃和心脏的影响,Palash Kar等人进行了一项前瞻性、单盲、随机、交叉研究。

该研究纳入了10名18-35岁的健康男性,受试者被随机分配至在最初12小时内先前低血糖-3期45min严格低血糖(2.8mmol/L)或对照-3期45min严格正常血糖(6mmol/L)。受试者被观察一夜,次日上午血糖控制在2.8mm/L 60min后控制在6mm/L 120min。至少6周之后受试者返回干预的治疗。于研究后4天上午用显像与二维超声心动图分别进行胃排空和心脏缩短率测定。

一次急性低血糖加速胃排空(P=0.01)和增强心脏部分缩短(p<0.01)。胃排空不受前期低血糖(P=0.74)的影响,而心脏部分缩短则呈衰减趋势(p=0.06)。先前低血糖反应降低肾上腺素反应(p<0.05)。

由上述研究可见在健康人群中,先前低血糖并不会影响后续低血糖所致的胃排空加速,却可能使心脏收缩力的增加减弱。

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    2018-02-27 smallant2015
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    2017-09-13 achengzhao
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    2017-08-31 QFXL123456

    学习了.谢谢!

    0

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    2017-08-06 虈亣靌

    学习了,谢谢分享

    0

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