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Amgen/Novartis偏头痛单克隆抗体Aimovig临床三期实验成功

2018-04-19 MedSci MedSci原创

偏头痛CGRP受体Aimovig
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IIIb期LIBERTY临床试验评估了Aimovig对尝试过2~4次治疗失败的发作性偏头痛患者的治疗作用，指的是"偏头痛预防试验中排除的独特难治性人群"。结果显示，服用该药物的患者偏头痛天数显着降低30.3％(安慰剂组为13.7％）。

世界卫生组织认为偏头痛是男性和女性残疾的十大原因之一，目前仍然是一个未得到满足的重大医疗领域。安进和诺华共同开发的Aimovig（erenumab）是全人源的单克隆抗体，专一性靶向和阻断降钙素基因相关肽（CGRP）受体，该受体被认为在介导偏头痛的失能性疼痛中起关键作用。

IIIb期LIBERTY临床试验评估了Aimovig对尝试过2~4次治疗失败的发作性偏头痛患者的治疗作用，指的是"偏头痛预防试验中排除的独特难治性人群"。结果显示，服用该药物的患者偏头痛天数显著降低30.3％(安慰剂组为13.7％）。

Uwe Reuter教授表示：“LIBERTY研究证明了靶向CGRP受体的抗体能够明显降低偏头痛发作频率及其相关负担，而这些患者在目前的预防性治疗方案中没有得到缓解。这些激动人心的数据为偏头痛患者提供了新的希望。”

Aimovig目前正在大西洋两岸进行审查，预计下个月会有美国FDA的决定。如果获得批准，诺华和安进将在美国共同销售Aimovig，而安进将保留该药物在日本的专利权，诺华保留世界其他地方的独家专利权。

原始出处：


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    2018-12-19 cenghis

    #Amgen#

    0

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    2019-01-15 aids221

    #克隆#

    0

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    2018-04-21 zhaojie88

    #ART#

    0

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    2018-04-21 zhouqu_8

    #AMG#

    0

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    2018-04-21 pcw110

    #Aimovig#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1746569, encodeId=456b1e46569ca, content=<a href='/topic/show?id=7344241edc' target=_blank style='color:#2F92EE;'>#Amgen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2417, encryptionId=7344241edc, topicName=Amgen)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e1735781236, createdName=cenghis, createdTime=Wed Dec 19 01:01:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1660159, encodeId=ef30166015992, content=<a href='/topic/show?id=8d0d28912db' target=_blank style='color:#2F92EE;'>#克隆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28912, encryptionId=8d0d28912db, topicName=克隆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596825099872, createdName=aids221, createdTime=Tue Jan 15 00:01:00 CST 2019, time=2019-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356766, encodeId=63941356e6675, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Apr 21 02:01:00 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439285, encodeId=cbf91439285b8, content=<a href='/topic/show?id=d087241211' target=_blank style='color:#2F92EE;'>#AMG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2412, encryptionId=d087241211, topicName=AMG)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Apr 21 02:01:00 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538758, encodeId=26711538e5843, content=<a href='/topic/show?id=8c82218170' target=_blank style='color:#2F92EE;'>#Aimovig#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2181, encryptionId=8c82218170, topicName=Aimovig)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c2413038577, createdName=pcw110, createdTime=Sat Apr 21 02:01:00 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307280, encodeId=550730e28057, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Thu Apr 19 12:46:08 CST 2018, time=2018-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307252, encodeId=627730e252ad, content=学习了.获益匪浅.感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Apr 19 11:12:44 CST 2018, time=2018-04-19, status=1, ipAttribution=)]
    2018-04-19 神功盖世

    阅

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1746569, encodeId=456b1e46569ca, content=<a href='/topic/show?id=7344241edc' target=_blank style='color:#2F92EE;'>#Amgen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2417, encryptionId=7344241edc, topicName=Amgen)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e1735781236, createdName=cenghis, createdTime=Wed Dec 19 01:01:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1660159, encodeId=ef30166015992, content=<a href='/topic/show?id=8d0d28912db' target=_blank style='color:#2F92EE;'>#克隆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28912, encryptionId=8d0d28912db, topicName=克隆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596825099872, createdName=aids221, createdTime=Tue Jan 15 00:01:00 CST 2019, time=2019-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356766, encodeId=63941356e6675, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Apr 21 02:01:00 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439285, encodeId=cbf91439285b8, content=<a href='/topic/show?id=d087241211' target=_blank style='color:#2F92EE;'>#AMG#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2412, encryptionId=d087241211, topicName=AMG)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Apr 21 02:01:00 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538758, encodeId=26711538e5843, content=<a href='/topic/show?id=8c82218170' target=_blank style='color:#2F92EE;'>#Aimovig#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2181, encryptionId=8c82218170, topicName=Aimovig)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c2413038577, createdName=pcw110, createdTime=Sat Apr 21 02:01:00 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307280, encodeId=550730e28057, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Thu Apr 19 12:46:08 CST 2018, time=2018-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=307252, encodeId=627730e252ad, content=学习了.获益匪浅.感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Apr 19 11:12:44 CST 2018, time=2018-04-19, status=1, ipAttribution=)]
    2018-04-19 虈亣靌

    学习了.获益匪浅.感谢分享

    0

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