Gastric Cancer: 不可切除的晚期胃癌患者血清碱性磷酸酶和乳酸脱氢酶水平的预后意义

2019-10-21 不详 MedSci原创

本项研究评估了碱性磷酸酶(ALP)和乳酸脱氢酶(LDH)对无法切除的晚期胃癌患者的预后价值。

背景
本项研究评估了碱性磷酸酶(ALP)和乳酸脱氢酶(LDH)对无法切除的晚期癌患者的预后价值。

方法
该研究招募了262例2007年至2015年在高知医学院接受化疗的无法切除的晚期癌患者。研究人员分析了临床病理学信息和全身炎症反应数据,以了解基线癌症相关的预后变量与生存结果之间的关联。

结果
高ALP,高LDH,高总胆红素,高天冬氨酸转氨酶,高丙氨酸转氨酶,高γ-谷氨酰转移酶,高肌酐,格拉斯哥预后评分(GPS)为1或2的患者的中位生存时间显着较低。多元生存分析确定高ALP 322(HR 1.808; 95%CI 1.015-3.220; P= 0.044),T2-3(HR 2.622; 95%CI 1.224-5.618; P= 0.013)和弥漫型胃癌(HR 2.325; 95%CI 1.341–4.032;P= 0.003)是癌症患者预后不良的重要独立预测因子。

结论
对于无法切除和复发的胃癌,接受化疗的患者,高水平的ALP是独立危险预后因素。

原始出处:

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    2020-05-03 skhzy
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    2020-07-19 许安
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    2019-10-22 147612bem32暂无昵称

    真好

    0

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