JAHA:先天性心脏病与心血管疾病风险

2019-05-15 xing.T 网络

由此可见,这项CHD队列研究的荟萃分析发现,CHD与晚年生活中心血管疾病风险增加存在相关性,虽然研究人员无法确定这种关联是否与冠心病幸存者心血管疾病的危险因素特征相混淆,或者CHD是否是一个独立的危险因素。

尽管先天性心脏病(CHD)的手术和药物治疗已经取得了显著成功,但一些幸存者长期仍然会出现血管并发症。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究的目的是通过对队列研究进行荟萃分析来评估CHD与心血管疾病(CVD)风险之间的关联。 

截至2018年4月,研究人员对几个数据库进行了系统的文献检索,以确定报告CHD幸存者心血管疾病、卒中、心力衰竭和冠状动脉心脏病风险的研究。研究人员使用纽卡斯尔-渥太华量表评估各个研究的质量,并使用固定效应荟萃分析汇总总体风险评估,以及进行亚组分析以探索异质性的可能来源。

该分析纳入了包括684200名参与者的9项队列研究。与对照者相比,CHD患者CVD的总体相对风险为的3.12(95%CI为3.01-3.24),卒中为2.46(95%CI为2.30-2.63),心力衰竭为5.89(95%CI为5.58-6.21),冠状动脉心脏病为1.5​​0(95%CI为1.40-1.61)。在这些风险评估的研究中发现了显著的异质性。CVD风险评估中的异质性可由地理区域、研究设计类型、样本来源、年龄组成和控制的混杂因素来解释。

由此可见,这项CHD队列研究的荟萃分析发现,CHD与晚年生活中心血管疾病风险增加存在相关性,虽然研究人员无法确定这种关联是否与冠心病幸存者心血管疾病的危险因素特征相混淆,或者CHD是否是一个独立的危险因素。 

原始出处:

Tingting Wang.et al.Congenital Heart Disease and Risk of Cardiovascular Disease: A Meta‐Analysis of Cohort Studies.JAHA.2019.https://www.ahajournals.org/doi/10.1161/JAHA.119.012030

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    2019-05-17 zhaohui6731
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    2019-05-17 huirong
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    2019-05-15 王秀

    学习了,涨知识了!

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