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JCEM：餐后饱和脂肪酸增加2型糖尿病的风险！

2018-02-02 xing.T MedSci原创

餐后饱和脂肪酸2型糖尿病风险
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由此可见，血清中更高的2h-SFA（但不是空腹SFA）水平可以独立预测糖尿病的风险。

实验证据表明饱和脂肪酸（SFA）与胰岛素抵抗（IR）有关，但来自于空腹SFA与糖尿病风险的流行病学研究结果并不一致。近日，内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章，研究人员旨在调查了SFA（空腹和餐后2h）的变化情况和糖尿病风险。

研究人员于2008年在哈尔滨健康研究中共招募8940名受试者，并测定了无糖尿病的汉族男性和女性基础血清SFA（空腹和餐后2h）水平，而在随访4-7年后采用WHO标准确定2型糖尿病的诊断。该研究的主要结局为餐后2h SFA（2h-SFA）水平与糖尿病之间的关系。

在基线情况下，发生糖尿病的患者年龄较大，体重指数（BMI）和腰围（WC）也较高。平均随访6.7年后，658名参与者发生糖尿病。在倾向评分（PS）计算和逆概率处理加权（IPTW）估计，研究人员发现空腹SFA与糖尿病风险无关，但餐后硬脂酸水平（2h-SA）、餐后棕榈酸（2h-PA）和2h-SFA水平位于最高三分位数范围的参与者糖尿病风险的IPTW调整后比值比和95%可信区间分别为2.50（2.08-3.16）、1.56（1.23-2.02）和1.70（1.34-2.17），趋势P＜0.0001。同样地，2h-SA/空腹SA、2h-PA/空腹PA和2h-SFA/空腹SFA比率预测糖尿病风险[IPTW调整后的比值比（95%可信区间）分别为：2.94（2.39-3.58）、2.31（1.80-2.93）和2.42（1.91-3.11），趋势P＜0.0001]。

由此可见，血清中更高的2h-SFA（但不是空腹SFA）水平可以独立预测糖尿病的风险。

原始出处：

Yanjiao Wang,et al. Postprandial saturated fatty acids increase the risk of type 2 diabetes: a cohort study in a Chinese population.J Clin Endocrinol Metab. 2018. https://doi.org/10.1210/jc.2017-01904

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    2018-10-11 achengzhao

    #JCE#

    0

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    2018-08-20 wwzzly

    #饱和脂肪酸#

    0

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    2018-08-13 smallant2015

    #JCEM#

    0

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    2018-02-24 天涯183

    非常好的文章.学习了

    0

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    2018-02-07 紫迎馨

    关注了

    0

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    2018-02-04 斯嘉莉

    #饱和脂肪#

    0

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    2018-02-03 天涯183

    非常好的文章.学习了

    0

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    2018-02-02 Doctor Peng

    不饱和脂肪酸是否存在相反情况呢?

    0

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    2018-02-02 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

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